High-intensity focused ultrasound (HIFU) in localized prostate cancer treatment

2015
journal article
review article
31
dc.abstract.enBackground: High-intensity focused ultrasound (HIFU) applies high-intensity focused ultrasound energy to locally heat and destroy diseased or damaged tissue through ablation. This study intended to review HIFU to explain the fundamentals of HIFU, evaluate the evidence concerning the role of HIFU in the treatment of prostate cancer (PC), review the technologies used to perform HIFU and the published clinical literature regarding the procedure as a primary treatment for PC. Material and Methods: Studies addressing HIFU in localized PC were identified in a search of internet scientific databases. The analysis of outcomes was limited to journal articles written in English and published between 2000 and 2013. Results: HIFU is a non-invasive approach that uses a precisely delivered ultrasound energy to achieve tumor cell necrosis without radiation or surgical excision. In current urological oncology, HIFU is used clinically in the treatment of PC. Clinical research on HIFU therapy for localized PC began in the 1990s, and the majority of PC patients were treated with the Ablatherm device. Conclusions: HIFU treatment for localized PC can be considered as an alternative minimally invasive therapeutic modality for patients who are not candidates for radical prostatectomy. Patients with lower pre-HIFU PSA level and favourable pathologic Gleason score seem to present better oncologic outcomes. Future advances in technology and safety will undoubtedly expand the HIFU role in this indication as more of patient series are published, with a longer follow-up period.pl
dc.contributor.authorAlkhorayef, Mohammedpl
dc.contributor.authorMahmoud, Mustafa Z.pl
dc.contributor.authorAlzimami, Khalid S.pl
dc.contributor.authorSulieman, Abdelmoneimpl
dc.contributor.authorFagiri, Maram A.pl
dc.date.accessioned2017-07-11T07:20:31Z
dc.date.available2017-07-11T07:20:31Z
dc.date.issued2015pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 140-141pl
dc.description.physical131-141pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume80pl
dc.identifier.doi10.12659/PJR.892341pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/42601
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enhigh-intensity focused ultrasound ablationpl
dc.subject.enmagnetic resonance imagingpl
dc.subject.enprostatic neoplasmspl
dc.subject.eninterventionalpl
dc.subtypeReviewArticlepl
dc.titleHigh-intensity focused ultrasound (HIFU) in localized prostate cancer treatmentpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: High-intensity focused ultrasound (HIFU) applies high-intensity focused ultrasound energy to locally heat and destroy diseased or damaged tissue through ablation. This study intended to review HIFU to explain the fundamentals of HIFU, evaluate the evidence concerning the role of HIFU in the treatment of prostate cancer (PC), review the technologies used to perform HIFU and the published clinical literature regarding the procedure as a primary treatment for PC. Material and Methods: Studies addressing HIFU in localized PC were identified in a search of internet scientific databases. The analysis of outcomes was limited to journal articles written in English and published between 2000 and 2013. Results: HIFU is a non-invasive approach that uses a precisely delivered ultrasound energy to achieve tumor cell necrosis without radiation or surgical excision. In current urological oncology, HIFU is used clinically in the treatment of PC. Clinical research on HIFU therapy for localized PC began in the 1990s, and the majority of PC patients were treated with the Ablatherm device. Conclusions: HIFU treatment for localized PC can be considered as an alternative minimally invasive therapeutic modality for patients who are not candidates for radical prostatectomy. Patients with lower pre-HIFU PSA level and favourable pathologic Gleason score seem to present better oncologic outcomes. Future advances in technology and safety will undoubtedly expand the HIFU role in this indication as more of patient series are published, with a longer follow-up period.
dc.contributor.authorpl
Alkhorayef, Mohammed
dc.contributor.authorpl
Mahmoud, Mustafa Z.
dc.contributor.authorpl
Alzimami, Khalid S.
dc.contributor.authorpl
Sulieman, Abdelmoneim
dc.contributor.authorpl
Fagiri, Maram A.
dc.date.accessioned
2017-07-11T07:20:31Z
dc.date.available
2017-07-11T07:20:31Z
dc.date.issuedpl
2015
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 140-141
dc.description.physicalpl
131-141
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
80
dc.identifier.doipl
10.12659/PJR.892341
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/42601
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
high-intensity focused ultrasound ablation
dc.subject.enpl
magnetic resonance imaging
dc.subject.enpl
prostatic neoplasms
dc.subject.enpl
interventional
dc.subtypepl
ReviewArticle
dc.titlepl
High-intensity focused ultrasound (HIFU) in localized prostate cancer treatment
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
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