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Constraint and adaptation in newt Toll-like receptor genes


Constraint and adaptation in newt Toll-like receptor genes

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dc.contributor.author Babik, Wiesław [SAP11018324] pl
dc.contributor.author Dudek, Katarzyna [SAP14008116] pl
dc.contributor.author Fijarczyk, Anna [SAP13037860] pl
dc.contributor.author Pabijan, Maciej [SAP11018728] pl
dc.contributor.author Stuglik, Michał [USOS13213] pl
dc.contributor.author Szkotak, Rafał pl
dc.contributor.author Zieliński, Piotr [SAP14008479] pl
dc.date.accessioned 2015-10-13T09:58:54Z
dc.date.available 2015-10-13T09:58:54Z
dc.date.issued 2015 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/16054
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Constraint and adaptation in newt Toll-like receptor genes pl
dc.type JournalArticle pl
dc.description.physical 81-95 pl
dc.description.additional Bibliogr. s. 92-95 pl
dc.abstract.en Acute die-offs of amphibian populations worldwide have been linked to the emergence of viral and fungal diseases. Inter and intraspecific immunogenetic differences may influence the outcome of infection. Toll-like receptors (TLRs) are an essential component of innate immunity and also prime acquired defenses. We report the first comprehensive assessment of TLR gene variation for urodele amphibians. The Lissotriton newt TLR repertoire includes representatives of 13 families and is compositionally most similar to that of the anuran Xenopus. Both ancient and recent gene duplications have occurred in urodeles, bringing the total number of TLR genes to at least 21. Purifying selection has predominated the evolution of newt TLRs in both long (∼70 Ma) and medium (∼18 Ma) timescales. However, we find evidence for both purifying and positive selection acting on TLRs in two recently diverged (2–5 Ma) allopatric evolutionary lineages (Lissotriton montandoni and L. vulgaris graecus). Overall, both forms of selection have been stronger in L. v. graecus, while constraint on most TLR genes in L. montandoni appears relaxed. The differences in selection regimes are unlikely to be biased by demographic effects because these were controlled by means of a historical demographic model derived from an independent data set of 62 loci. We infer that TLR genes undergo distinct trajectories of adaptive evolution in closely related amphibian lineages, highlight the potential of TLRs to capture the signatures of different assemblages of pathogenic microorganisms, and suggest differences between lineages in the relative roles of innate and acquired immunity. pl
dc.subject.en Approximate Bayesian Computation pl
dc.subject.en positive selection pl
dc.subject.en amphibia pl
dc.subject.en Toll-like receptors pl
dc.subject.en Lissotriton pl
dc.description.volume 7 pl
dc.description.number 1 pl
dc.identifier.doi 10.1093/gbe/evu266 pl
dc.identifier.eissn 1759-6653 pl
dc.title.journal Genome Biology and Evolution pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Nauk o Środowisku pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2015 A]: 35

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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa