Obrzęk szpiku u biorców przeszczepu nerki leczonych inhibitorami kalcyneuryny : opis przypadków

Bibliogr. s. 113

Background: Transient acute musculoskeletal pain syndrome occurs predominantly within the first several months after renal transplantation. Its pathogenesis is not well understood. The toxic effect of calcineurin inhibitors or steroids on bone metabolism has been suspected. Almost all reported cases were associated with the use of cyclosporin A. The pain typically involves distal part of lower extremities and arises in the feet, ankles, or knees. Case report: Two cases are presented of renal allograft recipients who developed severe lower-limb pain in the early period after transplantation while receiving calcineurin-inhibitor (cyclosporin A and tacrolimus). Results: We observed typical clinical and radiological symptoms. The final diagnosis was based on MRI scans. Relief from pain was observed during rest and elevation of the affected extremities. Clinical symptoms and MRI abnormalities resolved spontaneously within a few months.