Porównanie gęstości minerału kostnego u zdrowych dzieci z różnych populacji : przegląd piśmiennictwa

Bibliogr. s. 91-92

The aim of this study was to compare bone mineral density data assessed in healthy children from different populations in order to evaluate whether there are substantial differences among children bone mineralization data-sets worldwide. A literature search was performed for papers published during the last 15 years. We found 184 papers providing BMD data assessed in healthy children. To be eligible for the further analysis, the papers had to fit to selected criteria, such as the DXA pencil beam device used for total body, lumbar spine, or femur measurements; BMD data presented as g/cm2; and Caucasian children aged 4-20 years. Finally, 37 papers matched our criteria and the BMD data-sets were analyzed according to age and gender as well as the origin of the DXA devices (Hologic and Lunar). GraphPad Prism software was used to analyze the 139 groups of data-sets. Significant differences in age-, gender-, and device-matched BMD data were found in 38 of the 139 analyzed groups (27.3%). Two population-specific BMD data-sets assessed in healthy children markedly differed from the other data-sets in the whole analyzed age range. The apparent differences found in nearly 30% of the analyzed data-sets suggested that the tempo of bone mineralization as well as the amount of achieved BMD might be population specific. However, those differences might also be the consequence of different study design (cohort, prospective) as well as their varied scientific purposes. Moreover, the numbers of children included in the age and sex groups differed markedly. Analysis of published data on many populations indicates that substantial differences in bone mineral density data exist at least in some age groups of healthy children. However, these differences might also reflect different study purposes and designs. Therefore there is a substantial need to establish population-specific reference BMD data based on studies with a consistent study design.