Local response of esophageal carcinoma to neoadjuvant chemotherapy in CT examination according to WHO and RECIST criteria

Local response of esophageal carcinoma to neoadjuvant ...

Bibliographic description

title:	Local response of esophageal carcinoma to neoadjuvant chemotherapy in CT examination according to WHO and RECIST criteria
alternative title:	Ocena stopnia miejscowej odpowiedzi raka przełyku na chemioterapię przedoperacyjną w tomografii komputerowej : kryteria WHO i RECIST
author:	Pasławski Marek, Kołtyś Witold, Złomaniec Janusz
Journal title:	Polish Journal of Radiology
volume:	71
issue:	3
date of publication:	2006
pages:	7-10
article ID:	456358
ISSN:	1733-134X
eISSN:	1899-0967
URL:	http://archiwum.inforadiologia.pl/download/index/idArt/456358.html
date accessed:	2019-08-16
notes:	Bibliogr. s. 10
language:	Polish
Journal language:	Polish
abstract in english:	Background: The aim of the study was to compare the WHO and RECIST criteria of esophageal carcinoma chemotherapy response. Material/Methods: Neoadjuvant chemotherapy was applied in a group of 52 patients with esophageal carcinoma. CT examination of the esophagus was performed in all of them before and after the appropriate course of therapy and chemotherapy response was assessed according to both WHO and RECIST criteria. The results were analyzed using the statistical software Statistica PL 5.0. Results: Complete response was found in 8 patients according to both WHO and RECIST criteria. Partial response was found in 8 patients according to WHO criteria and in 19 patients according to RECIST criteria. Stabile disease was found in 32 patients according to WHO criteria and in 20 patients according to RECIST criteria. Progression of the disease was found in 4 patients according to WHO criteria and in 5 according to RECIST. Eleven patients classified as having stabilization of the disease according to WHO criteria were classified as having partial response according to RECIST criteria. One patient classified as having stabilization of the disease according to WHO criteria was classified as having progression according to RECIST criteria. The difference was statistically significant (p=0.012). Conclusions: There are statistically significant differences between the WHO and RECIST classifications of chemotherapy response in esophageal carcinoma. The classification system must be determined when chemotherapy response is assessed. Determining which one, WHO or RECIST, is more suitable for assessing chemotherapy response of esophageal carcinoma requires additional study, including an evaluation of the survival rate in responders according to both systems.
keywords in english:	esophageal carcinoma, neoadjuvant chemotherapy, WHO criteria, RECIST criteria
type:	journal article
subtype:	academic paper

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