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Assessment of brain phenylalanine dynamics in phenylketonuria patients
2006
journal article
article
Journal
Polish Journal of Radiology
Alternative title
Ocena dynamiki mózgowego stężenia fenyloalaniny u pacjentów z fenyloketonurią
Author
Bik-Multanowski Mirosław
Pietrzyk Jacek J.
Pasowicz Mieczyslaw
Banys R. Pawel
Volume
71
Number
2
Pages
24-25
Article ID
451183
ISSN
1733-134X
eISSN
1899-0967
Keywords in English
blood-brain barrier
amino acid transport
Access date
2019-07-10
Remarks
Bibliogr. s. 25
Language
English
Journal language
Polish
Abstract in English
Background: Phenylketonuria (PKU) is the most common inborn error of metabolism in man. Brain phenylalanine kinetics can determine neurological treatment outcome in phenylketonuria. The aim of our study was to test a simplified magnetic resonance spectroscopy method for assessment of brain phenylalanine dynamics in PKU patients. Material/Methods: Brain phenylalanine concentration (measured by means of magnetic resonance spectroscopy) and blood phenylalanine concentrations changes occurring within 24 hours after oral phenylalanine loading were analyzed in 5 PKU patients. Results/Conclusions: The brain/blood phenylalanine ratio in 3 persons with normal intelligence was lower than in 2 with borderline intelligence or mild mental retardation. In our opinion the proposed method could be useful for assessment of brain phenylalanine dynamics in PKU patients.
Affiliation
Wydział Lekarski : Instytut Pediatrii
| dc.abstract.en | Background: Phenylketonuria (PKU) is the most common inborn error of metabolism in man. Brain phenylalanine kinetics can determine neurological treatment outcome in phenylketonuria. The aim of our study was to test a simplified magnetic resonance spectroscopy method for assessment of brain phenylalanine dynamics in PKU patients. Material/Methods: Brain phenylalanine concentration (measured by means of magnetic resonance spectroscopy) and blood phenylalanine concentrations changes occurring within 24 hours after oral phenylalanine loading were analyzed in 5 PKU patients. Results/Conclusions: The brain/blood phenylalanine ratio in 3 persons with normal intelligence was lower than in 2 with borderline intelligence or mild mental retardation. In our opinion the proposed method could be useful for assessment of brain phenylalanine dynamics in PKU patients. | pl |
| dc.affiliation | Wydział Lekarski : Instytut Pediatrii | pl |
| dc.contributor.author | Bik-Multanowski, Mirosław - 128777 | pl |
| dc.contributor.author | Pietrzyk, Jacek J. - 133150 | pl |
| dc.contributor.author | Pasowicz, Mieczyslaw | pl |
| dc.contributor.author | Banys, R. Pawel | pl |
| dc.date.accession | 2019-07-10 | pl |
| dc.date.accessioned | 2019-07-10T15:05:39Z | |
| dc.date.available | 2019-07-10T15:05:39Z | |
| dc.date.issued | 2006 | pl |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.additional | Bibliogr. s. 25 | pl |
| dc.description.number | 2 | pl |
| dc.description.physical | 24-25 | pl |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 71 | pl |
| dc.identifier.articleid | 451183 | pl |
| dc.identifier.eissn | 1899-0967 | pl |
| dc.identifier.issn | 1733-134X | pl |
| dc.identifier.project | ROD UJ / OP | pl |
| dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/78843 | |
| dc.identifier.weblink | http://archiwum.inforadiologia.pl/download/index/idArt/451183.html | pl |
| dc.language | eng | pl |
| dc.language.container | pol | pl |
| dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa | * |
| dc.rights.licence | CC-BY-NC-ND | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl | * |
| dc.share.type | otwarte czasopismo | |
| dc.subject.en | blood-brain barrier | pl |
| dc.subject.en | amino acid transport | pl |
| dc.subtype | Article | pl |
| dc.title | Assessment of brain phenylalanine dynamics in phenylketonuria patients | pl |
| dc.title.alternative | Ocena dynamiki mózgowego stężenia fenyloalaniny u pacjentów z fenyloketonurią | pl |
| dc.title.journal | Polish Journal of Radiology | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |
dc.abstract.enpl
Background: Phenylketonuria (PKU) is the most common inborn error of metabolism in man. Brain phenylalanine kinetics can determine neurological treatment outcome in phenylketonuria. The aim of our study was to test a simplified magnetic resonance spectroscopy method for assessment of brain phenylalanine dynamics in PKU patients. Material/Methods: Brain phenylalanine concentration (measured by means of magnetic resonance spectroscopy) and blood phenylalanine concentrations changes occurring within 24 hours after oral phenylalanine loading were analyzed in 5 PKU patients. Results/Conclusions: The brain/blood phenylalanine ratio in 3 persons with normal intelligence was lower than in 2 with borderline intelligence or mild mental retardation. In our opinion the proposed method could be useful for assessment of brain phenylalanine dynamics in PKU patients. dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii dc.contributor.authorpl
Bik-Multanowski, Mirosław - 128777 dc.contributor.authorpl
Pietrzyk, Jacek J. - 133150 dc.contributor.authorpl
Pasowicz, Mieczyslaw dc.contributor.authorpl
Banys, R. Pawel dc.date.accessionpl
2019-07-10 dc.date.accessioned
2019-07-10T15:05:39Z dc.date.available
2019-07-10T15:05:39Z dc.date.issuedpl
2006 dc.date.openaccess
0 dc.description.accesstime
w momencie opublikowania dc.description.additionalpl
Bibliogr. s. 25 dc.description.numberpl
2 dc.description.physicalpl
24-25 dc.description.version
ostateczna wersja wydawcy dc.description.volumepl
71 dc.identifier.articleidpl
451183 dc.identifier.eissnpl
1899-0967 dc.identifier.issnpl
1733-134X dc.identifier.projectpl
ROD UJ / OP dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/78843 dc.identifier.weblinkpl
http://archiwum.inforadiologia.pl/download/index/idArt/451183.html dc.languagepl
eng dc.language.containerpl
pol dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa dc.rights.licence
CC-BY-NC-ND dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl dc.share.type
otwarte czasopismo dc.subject.enpl
blood-brain barrier dc.subject.enpl
amino acid transport dc.subtypepl
Article dc.titlepl
Assessment of brain phenylalanine dynamics in phenylketonuria patients dc.title.alternativepl
Ocena dynamiki mózgowego stężenia fenyloalaniny u pacjentów z fenyloketonurią dc.title.journalpl
Polish Journal of Radiology dc.typepl
JournalArticle dspace.entity.type
Publication Affiliations
No affiliation
Bik-Multanowski, Mirosław
Pietrzyk, Jacek J.
Pasowicz, Mieczyslaw
Banys, R. Pawel
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