Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results

doi:10.5114/pjr.2019.84274

Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results

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Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results

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title:	Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis : preliminary results
author:	Marciniewicz Ewelina, Pokryszko-Dragan Anna, Podgórski Przemysław, Małyszczak Krzysztof, Zimny Anna, Kołtowska Anna, Budrewicz Sławomir, Sąsiadek Marek, Bladowska Joanna
journal title:	Polish Journal of Radiology
volume:	84
date of publication :	2019
pages:	e171-e178
ISSN:	1733-134X
eISSN:	1899-0967
DOI:	10.5114/pjr.2019.84274
notes:	Bibliogr. s. e177-e178
language:	English
journal language:	English
abstract in English:	Purpose: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. Material and methods: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. Results: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. Conclusions: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease.
keywords in English:	multiple sclerosis, magnetic resonance volumetry, neurocognitive dysfunction, EDSS, brain atrophy
type:	journal article
subtype:	academic paper

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