Simple view
Full metadata view
Authors
Statistics
Microwave-assisted hydrolysis and extraction of tricyclic antidepressants from human hair
Journal
Analytical and Bioanalytical Chemistry
Author
Wietecha-Posłuszny Renata
Garbacik Aneta
Woźniakiewicz Michał
Kościelniak Paweł
Volume
399
Number
9
Title of volume
Focus on Analytical Science in Poland (VIIIth Polish Conference on Analytical Chemistry)
Pages
3233-3240
ISSN
1618-2642
eISSN
1618-2650
Keywords in English
tricyclic antidepressants
hair analysis
microwave-assisted hydrolysis
microwave-assisted extraction
Access date
2019-03-26
Remarks
Bibliogr. s. 3240.
Language
English
Journal language
English
Abstract in English
The objective of this research was to develop, optimize, and validate a modern, rapid method of preparation of human hair samples, using microwave irradiation, for analysis of eight tricyclic antidepressants (TCADs): nordoxepin, nortriptyline, imipramine, amitriptyline, doxepin, desipramine, clomipramine, and norclomipramine. It was based on simultaneous alkaline hair microwave-assisted hydrolysis and microwave-assisted extraction (MAH–MAE). Extracts were analyzed by high-performance liquid chromatography with diode-array detection (HPLC–DAD). A mixture of n-hexane and isoamyl alcohol (99:1, v/v) was used as extraction solvent and the process was performed at 60°C. Application of 1.0 mol L-1 NaOH and microwave irradiation for 40 min were found to be optimum for hair samples. Limits of detection ranged from 0.3 to 1.2 μg g−1 and LOQ from 0.9 to 4.0 μg g−1 for the different drugs. This enabled us to quantify them in hair samples within average therapeutic concentration ranges.
Affiliation
Wydział Chemii : Zakład Chemii Analitycznej
Scopus© citations
13
| cris.lastimport.wos | 2024-04-09T19:10:54Z | |
| dc.abstract.en | The objective of this research was to develop, optimize, and validate a modern, rapid method of preparation of human hair samples, using microwave irradiation, for analysis of eight tricyclic antidepressants (TCADs): nordoxepin, nortriptyline, imipramine, amitriptyline, doxepin, desipramine, clomipramine, and norclomipramine. It was based on simultaneous alkaline hair microwave-assisted hydrolysis and microwave-assisted extraction (MAH–MAE). Extracts were analyzed by high-performance liquid chromatography with diode-array detection (HPLC–DAD). A mixture of n-hexane and isoamyl alcohol (99:1, v/v) was used as extraction solvent and the process was performed at 60°C. Application of 1.0 mol L-1 NaOH and microwave irradiation for 40 min were found to be optimum for hair samples. Limits of detection ranged from 0.3 to 1.2 μg g−1 and LOQ from 0.9 to 4.0 μg g−1 for the different drugs. This enabled us to quantify them in hair samples within average therapeutic concentration ranges. | pl |
| dc.affiliation | Wydział Chemii : Zakład Chemii Analitycznej | pl |
| dc.contributor.author | Wietecha-Posłuszny, Renata - 132627 | pl |
| dc.contributor.author | Garbacik, Aneta | pl |
| dc.contributor.author | Woźniakiewicz, Michał - 142043 | pl |
| dc.contributor.author | Kościelniak, Paweł - 129217 | pl |
| dc.date.accession | 2019-03-26 | pl |
| dc.date.accessioned | 2019-03-27T09:46:41Z | |
| dc.date.available | 2019-03-27T09:46:41Z | |
| dc.date.issued | 2011 | pl |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.additional | Bibliogr. s. 3240. | pl |
| dc.description.number | 9 | pl |
| dc.description.physical | 3233-3240 | pl |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 399 | pl |
| dc.identifier.doi | 10.1007/s00216-010-4440-y | pl |
| dc.identifier.eissn | 1618-2650 | pl |
| dc.identifier.issn | 1618-2642 | pl |
| dc.identifier.project | ROD UJ / OP | pl |
| dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/71508 | |
| dc.identifier.weblink | https://link.springer.com/content/pdf/10.1007%2Fs00216-010-4440-y.pdf | pl |
| dc.language | eng | pl |
| dc.language.container | eng | pl |
| dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne | * |
| dc.rights.licence | CC-BY-NC | |
| dc.rights.uri | http://creativecommons.org/licenses | * |
| dc.share.type | inne | |
| dc.subject.en | tricyclic antidepressants | pl |
| dc.subject.en | hair analysis | pl |
| dc.subject.en | microwave-assisted hydrolysis | pl |
| dc.subject.en | microwave-assisted extraction | pl |
| dc.subtype | Article | pl |
| dc.title | Microwave-assisted hydrolysis and extraction of tricyclic antidepressants from human hair | pl |
| dc.title.journal | Analytical and Bioanalytical Chemistry | pl |
| dc.title.volume | Focus on Analytical Science in Poland (VIIIth Polish Conference on Analytical Chemistry) | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |
cris.lastimport.wos
2024-04-09T19:10:54Z dc.abstract.enpl
The objective of this research was to develop,
optimize, and validate a modern, rapid method of preparation
of human hair samples, using microwave irradiation, for
analysis of eight tricyclic antidepressants (TCADs): nordoxepin,
nortriptyline, imipramine, amitriptyline, doxepin, desipramine,
clomipramine, and norclomipramine. It was based on simultaneous alkaline hair microwave-assisted hydrolysis and
microwave-assisted extraction (MAH–MAE). Extracts were
analyzed by high-performance liquid chromatography with
diode-array detection (HPLC–DAD). A mixture of n-hexane
and isoamyl alcohol (99:1, v/v) was used as extraction solvent
and the process was performed at 60°C. Application of
1.0 mol L-1 NaOH and microwave irradiation for 40 min
were found to be optimum for hair samples. Limits of detection
ranged from 0.3 to 1.2 μg g−1 and LOQ from 0.9 to 4.0 μg g−1
for the different drugs. This enabled us to quantify them in
hair samples within average therapeutic concentration ranges. dc.affiliationpl
Wydział Chemii : Zakład Chemii Analitycznej dc.contributor.authorpl
Wietecha-Posłuszny, Renata - 132627 dc.contributor.authorpl
Garbacik, Aneta dc.contributor.authorpl
Woźniakiewicz, Michał - 142043 dc.contributor.authorpl
Kościelniak, Paweł - 129217 dc.date.accessionpl
2019-03-26 dc.date.accessioned
2019-03-27T09:46:41Z dc.date.available
2019-03-27T09:46:41Z dc.date.issuedpl
2011 dc.date.openaccess
0 dc.description.accesstime
w momencie opublikowania dc.description.additionalpl
Bibliogr. s. 3240. dc.description.numberpl
9 dc.description.physicalpl
3233-3240 dc.description.version
ostateczna wersja wydawcy dc.description.volumepl
399 dc.identifier.doipl
10.1007/s00216-010-4440-y dc.identifier.eissnpl
1618-2650 dc.identifier.issnpl
1618-2642 dc.identifier.projectpl
ROD UJ / OP dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/71508 dc.identifier.weblinkpl
https://link.springer.com/content/pdf/10.1007%2Fs00216-010-4440-y.pdf dc.languagepl
eng dc.language.containerpl
eng dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne dc.rights.licence
CC-BY-NC dc.rights.uri*
http://creativecommons.org/licenses dc.share.type
inne dc.subject.enpl
tricyclic antidepressants dc.subject.enpl
hair analysis dc.subject.enpl
microwave-assisted hydrolysis dc.subject.enpl
microwave-assisted extraction dc.subtypepl
Article dc.titlepl
Microwave-assisted hydrolysis and extraction of tricyclic antidepressants from human hair dc.title.journalpl
Analytical and Bioanalytical Chemistry dc.title.volumepl
Focus on Analytical Science in Poland (VIIIth Polish Conference on Analytical Chemistry) dc.typepl
JournalArticle dspace.entity.type
Publication Affiliations
No affiliation
Wietecha-Posłuszny, Renata
Garbacik, Aneta
Woźniakiewicz, Michał
Kościelniak, Paweł
* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.
Open Access
Loading...
