Impact of vanadium complexes treatment on the oxidative stress factors in Wistar rats plasma

doi:10.1155/2011/206316

Impact of vanadium complexes treatment on the oxidative stress factors in Wistar rats plasma

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Impact of vanadium complexes treatment on the oxidative stress factors in Wistar rats plasma

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Bibliographic description

punktacja MEiN [2011 A]: 20

title:	Impact of vanadium complexes treatment on the oxidative stress factors in Wistar rats plasma
author:	Francik Renata , Krośniak Mirosław , Barlik Mateusz, Kudła Agnieszka, Gryboś Ryszard , Librowski Tadeusz
journal title:	Bioinorganic Chemistry and Applications
volume:	2011
date of publication :	2011
article ID:	206316
ISSN:	1565-3633
eISSN:	1687-479X
DOI:	10.1155/2011/206316
URL:	https://www.hindawi.com/journals/bca/2011/206316/
date accessed:	2019-03-27
notes:	Bibliogr. 206316-7 - 206316-8.
language:	English
journal language:	English
abstract in English:	The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP-ferric reducing ability of plasma, and reduced glutathione-GSH) and enzymatic (glutathione peroxidase-GPx, catalase-CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4·2H2O, [VO(4,4 Me2bpy)2]SO4·2H2O, and Na[VO(O2)2(bpy)]·8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others.
affiliation:	Wydział Chemii : Zakład Chemii Nieorganicznej, Wydział Farmaceutyczny : Zakład Radioligandów, Wydział Farmaceutyczny : Zakład Bromatologii, Wydział Farmaceutyczny : Zakład Chemii Bioorganicznej
type:	journal article
subtype:	academic paper