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Background: Septic cerebral sinus thrombosis is a relatively uncommon but a serious neurologic disorder. Imaging plays a crucial role in the diagnosis. Knowledge of venous anatomy, anatomical variants and potential pitfalls related to image interpretation are important for achieving a quick and accurate diagnosis. Case Report: We present the case of the patient with severe headache and photophobia which appeared during infection of upper respiratory tract. The provisional diagnosis was a subarachnoid hemorrhage but CT of the head did not reveal any abnormality. MRI of the head showed signs suggestive for the septic cerebral sinus thrombosis. The patient responded well to the antibiotic and anticoagulant therapy. Conclusions: The septic cerebral sinus thrombosis may present in a number of guises so it is impossible to establish a right diagnosis based only on clinical presentation. Imaging examinations in most cases reveal typical abnormalities. Various CT and MRI techniques play a crucial role in the process of diagnosing.