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Background: Primary renal lymphoma is a very rare and controversial disease entity. Diagnostic criteria and therapeutic procedure are not obvious. However, a few cases have been reported in the world literature. Pathological symptoms and radiological manifestation are not typical. Correct diagnosis is established thanks to renal biopsy. Even though curative algorithm is not clear, the fact is that early diagnosis and treatment have a big influence on prognosis as to life. Case Report: We report the case of 81 year old women which was diagnosed due to nonspecific symptoms. Laboratory investigation reveals hypercalcaemia, high C-reactive protein, and urinary tract infection with leucocyturia, erythrocyturia, bacteriuria. Ultrasonography of the abdomen exposes hypo-echoic area in the inferior pole of the left kidney. CT scanning discloses hypodensive and poorly enhancing masses in this region. The diagnosis of primary renal lymphoma, diffuse large B-cell type was established, thanks to histological examination of biopsy material. After surgical intervention patient started polychemotherapy. Conclusions: Although primary renal lymphoma is an uncommon disease it should be included in the differential diagnosis for renal masses. That procedure could accelerate correct diagnosis and treatment, which in the future could make better prognosis as to life.