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The utility of ADC measurement techniques for differentiation of low- and high-grade clear cell RCC

The utility of ADC measurement techniques for ...

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dc.contributor.author Aslan, Ahmet pl
dc.contributor.author İnan, İbrahim pl
dc.contributor.author Aktan, Ahmet pl
dc.contributor.author Ayaz, Ercan pl
dc.contributor.author Aslan, Mine pl
dc.contributor.author Özkanlı, Sıdıka Şeyma pl
dc.contributor.author Yildirim, Asif pl
dc.contributor.author Yıkılmaz, Ali pl
dc.date.accessioned 2018-12-06T08:47:19Z
dc.date.available 2018-12-06T08:47:19Z
dc.date.issued 2018 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/62750
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title The utility of ADC measurement techniques for differentiation of low- and high-grade clear cell RCC pl
dc.type JournalArticle pl
dc.description.physical e446-e451 pl
dc.description.additional Bibliogr. s. e451 pl
dc.abstract.en Purpose: To evaluate the diffusion properties of clear cell renal cell carcinoma (ccRCC) on magnetic resonance imaging (MRI) concerning their Fuhrman nuclear grades and sizes, and to compare the diagnostic performance of two ROI placement techniques for apparent diffusion coefficient (ADC) measurement (entire mass vs. only the darkest region of the mass). Material and methods: Fifty-one ccRCC were enrolled in the study and grouped into low-grade ccRCC (Fuhrman grade 1 and 2, n = 37) and high-grade ccRCC (Fuhrman grade 3 and 4, n = 14). Selective ADC (Sel-ADC) measurement was performed by placing a circular ROI that included the darkest region of the tumour on ADC map images. Extensive ADC (Ext-ADC) measurement was performed by drawing an ROI that covered the entire tumour. Results: The Sel-ADC value was lower in high-grade ccRCC (p = 0.019), whereas the Ext-ADC value did not show a statistically significant difference (p = 0.42). Sel-ADC value of a ≤ 1.405 mm2/s has a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy value of 78.6, 72.2, 73.87, 77.13, and 75.4, respectively, to differentiate high-grade from low-grade ccRCC. The size and Fuhrman grade of the ccRCC were inversely correlated with the Sel-ADC value; however, the correlations were weak (r = -0.322, p = 0.021 and r = -0.376, p = 0.006, respectively). There was no difference between ADC values of small (≤ 4 cm) and large (> 4 cm) ccRCCs. Conclusions: The ADC value of the darkest region in solid part of the ccRCC may play a role in predicting the nuclear grade of ccRCC. pl
dc.subject.en magnetic resonance imaging pl
dc.subject.en apparent diffusion coefficient pl
dc.subject.en clear cell renal cell carcinoma pl
dc.subject.en diffusion-weighted imaging pl
dc.subject.en Fuhrman grading system pl
dc.description.volume 83 pl
dc.identifier.doi 10.5114/pjr.2018.80207 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa