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Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering
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Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering
Bibliographic description
| title: | Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering |
| author: | Zuber Aleksandra, Borowczyk-Michałowska Julia  , Zimoląg Eliza , Krok Małgorzata, Madeja Zbigniew , Pamuła Elżbieta, Drukała Justyna
|
| journal title: | Cellular & Molecular Biology Letters |
| volume: | 19 |
| issue: | 2 |
| date of publication : | 2014 |
| pages: | 297-314 |
| ISSN: |
1425-8153 |
| eISSN: |
1689-1392 |
| DOI: | |
| notes: | Julia Borowczyk-Michałowska podpisana: Julia Borowczyk |
| language: | English |
| journal language: | English |
| abstract in English: | Degradable aliphatic polyesters such as polylactides, polyglycolides and their copolymers are used in several biomedical and pharmaceutical applications. We analyzed the influence of poly(L-lactide-co-glycolide) (PLGA) thin films on the adhesion, proliferation, motility and differentiation of primary human skin keratinocytes and fibroblasts in the context of their potential use as cell carriers for skin tissue engineering. We did not observe visible differences in the morphology, focal contact appearance, or actin cytoskeleton organization of skin cells cultured on PLGA films compared to those cultured under control conditions. Moreover, we did not detect biologically significant differences in proliferative activity, migration parameters, level of differentiation, or expression of vinculin when the cells were cultured on PLGA films and tissue culture polystyrene. Our results indicate that PLGA films do not affect the basic functions of primary human skin keratinocytes and fibroblasts and thus show acceptable biocompatibility in vitro, paving the way for their use as biomaterials for skin tissue engineering. |
| keywords in English: | burns, wound healing, skin regeneration, keratinocytes, fibroblasts, biomaterials, tissue engineering, PLGA, full-thickness burns |
| affiliation: | Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórki |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
