Purpose: The aim of this study was to identify the top 50 cited articles on the use of cone-beam computed tomography (CBCT) for oral and maxillofacial applications and to summarise the characteristics of the most impactful research articles in this domain. Material and methods: A database was generated by combining the search results from Thomson Reuters Web of Science and Elsevier's Scopus to ensure that all top-cited publications were captured. We used three search fields to generate the database: 1) CBCT, 2) oral and maxillofacial pathologies, and 3) oral and maxillofacial anatomical structures. Publications were then ranked by citation counts and reviewed by two independent reviewers. Results: A total of 50 top publications were included in the study. Their citation count ranged from 43 to 170 with a median of 55.5. Five publications were cited more than 100 times. All except for one paper were published after 2000. The most well published journal was the American Journal of Orthodontics and Dentofacial Orthopedics (n = 12), and the United States of America (n = 15) was the most productive country in the field. The majority of the studies (n = 27) discussed the imaging of primary tooth pathologies, but there are also a significant number of articles that discuss imaging of bone grafts or dental implants (n = 7), upper airways (n = 5), the skull (n = 4), and other maxillofacial structures (n = 7). Conclusions: Our study identifies 50 research articles with the highest number of citations in oral and maxillofacial CBCT, discusses the characteristics and commonalities between these articles, and predicts future trends in the field.