In the present study, we applied the quest for significance model of radicalization to explain the use of politicalviolence. According to the model, when people experience loss of personal significance (e.g., due to socialrejection, achievement failures, or abuse) the motivation to restore significance may push them toward the useof extreme means. We tested this prediction in a sample of individuals who have committed ideologicallymotivated crimes in the United States (n 5 1496). We found that experiences of economic and social loss ofsignificance were separate and positive predictors related to the use of violence by perpetrators ofideologically motivated crimes. We also found evidence that the presence of radicalized others (friends but notfamily members) in the individuals’ social network increased their likelihood of using violence.