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Neuroimaging in the differential diagnosis of primary progressive aphasia : illustrative case series in the light of new diagnostic criteria

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Neuroimaging in the differential diagnosis of primary progressive aphasia : illustrative case series in the light of new diagnostic criteria

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dc.contributor.author Sitek, Emilia J. pl
dc.contributor.author Narożańska, Ewa pl
dc.contributor.author Brockhuis, Bogna pl
dc.contributor.author Muraszko-Klaudel, Anna pl
dc.contributor.author Lass, Piotr pl
dc.contributor.author Harciarek, Michał pl
dc.contributor.author Sławek, Jarosław pl
dc.date.accessioned 2017-08-11T06:42:15Z
dc.date.available 2017-08-11T06:42:15Z
dc.date.issued 2014 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/43173
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode *
dc.title Neuroimaging in the differential diagnosis of primary progressive aphasia : illustrative case series in the light of new diagnostic criteria pl
dc.type JournalArticle pl
dc.description.physical 251-258 pl
dc.description.additional Bibliogr. s. 258 pl
dc.abstract.en Background: Primary progressive aphasia (PPA) is a progressive language disorder associated with atrophy of the dominant language hemisphere, typically left. Current PPA criteria divide PPA into three variants: non-fluent (nfvPPA), semantic (svPPA) and logopenic (lvPPA). The classification of PPA into one of the three variants may be performed at 3 levels: I) clinical, II) imaging-supported, III) definite pathologic diagnosis. This paper aimed at assessing the feasibility of the imaging-supported diagnostics of PPA variants in the Polish clinical setting with access to magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) examinations. Case Report: We present the clinical and neuroimaging data on 6 patients (4 women, 2 men) clinically diagnosed with PPA (3 with nfvPPA and 3 with lvPPA) in whom MRI and SPECT were performed in order to determine if imaging-supported diagnosis could be established in those cases. In 4 individuals (2 with nfvPPA and 2 with lvPPA) clinical diagnosis was supported by neuroimaging (SPECT, albeit not MRI), thus level II of PPA diagnosis could be established in those cases. MRI results were either inconsistent with the clinical diagnosis (Patients 1 and 2) or a mixed pattern of atrophy was observed (Patients 3-6). Conclusions: Imaging-supported diagnosis of PPA variant is more feasible with quantitative analysis of SPECT images than with purely qualitative visual analysis of MRI. Hypoperfusion abnormalities evidenced by SPECT are more variant-specific than patterns of atrophy. pl
dc.subject.en primary progressive aphasia pl
dc.subject.en frontotemporal dementia pl
dc.subject.en magnetic resonance imaging (MRI) pl
dc.subject.en single photon-emission computerized tomography (SPECT) pl
dc.description.volume 79 pl
dc.identifier.doi 10.12659/PJR.890320 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska