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Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides
Bibliographic description
| title: | Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides |
| author: | Ciszek-Lenda Marta  , Strus Magdalena , Górska-Frączek Sabina, Targosz-Korecka Marta , Śróttek Małgorzata , Heczko Piotr , Gamian Andrzej, Szymoński Marek , Marcinkiewicz Janusz
|
| journal title: | Central-European Journal of Immunology |
| volume: | 36 |
| issue: | 3 |
| date of publication : | 2011 |
| pages: | 121-129 |
| ISSN: |
1426-3912 |
| eISSN: |
1644-4124 |
| URL: | |
| date accessed: |
2017-01-03 |
| language: | English |
| journal language: | English |
| abstract in English: | Lactobacilli, the most commonly used probiotics, show strain specific immunostimulatory effects. The strain specificity is related to the structure of cell-wall components such as lipoteichoic acids (LTAs), ligands for TLR2. In contrast, the role of exopolysaccharides (EPSs), the major components of lactobacilli biofilm, in the “cross-talk” between bacteria and the immune system is poorly documented. In this study, we have tested immunomodulating potential of lactobacilli derived EPSs, by their ability to modulate in vitro production of cytokines by murine peritoneal macrophages. We have examined EPSs of three lactobacilli strains (L. reuteri, L. johnsonii, L. animalis/murinus) isolated from colitic mice. The effect was compared with that of whole bacteria and LTA. All three nonviable Lactobacillus strains induced high amounts of cytokines with a strain specific profile. In contrast, the tested exopolysaccharides, exert low, albeit highly strain diversified stimulatory activities. The immunostimulatory potential of EPSs was correlated with the interaction strength between EPS and macrophage receptors as measured by atomic force spectroscopy. |
| keywords in English: | cytokines, macrophages, lipoteichoic acid (LTA), exopolysaccharide (EPS), probiotics, lactobacilli |
| affiliation: | Wydział Lekarski : Zakład Immunologii, Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego, Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
