Online First 2023-08-07

Purpose: The sphenoid bone (SB) extracranial ligaments (ECRLs) are the pterygoalar and pterygospinous ligaments (PTAL and PTSL) that are located at the SB lateral pterygoid plate, and inferior to the foramen ovale (FO). Their ossification may affect the mandibular nerve’s distribution. The intracranial ligaments’ (ICRLs) ossification (the caroticoclinoid ligament—CCLL, the anterior and posterior interclinoid ligaments—AICLL and PICLL) may impede the approaches to the sella. This study highlights the incidence of the ossified ECRLs and ICRLs location, their type (partial, or complete), considering laterality, gender, age, and ligaments’ simultaneous presence. Methods: The sample consisted of 156 Greek adult dried skulls of both genders and variable age. Results: Ossified ligaments were identified in 57.05%, predominantly extracranially (42.31%, P = 0.003). ECRLs were predominantly identified unilaterally (30.13%, P < 0.001). The majority of the ossified ICRLs were predominantly identified in male skulls (31.1%, P = 0.048) and the majority of the ECRLs (52.8%, P = 0.028) were predominantly identified at the age of 60 years and above. The PTAL was the most ossified (32.69%), followed by the CCLL (24.36%), the PTSL (16.03%), the PICLL (6.41%), and the AICLL (4.49%). Conclusions: Detailed knowledge of the SB morphology and ligaments’ ossification extent is essential to improve the technique of the FO percutaneous approach, and sellar approaches, to minimize complications.