Repozytorium Uniwersytetu Jagiellońskiego
An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
An inhibitory effect of interferon gamma on the ...
Opis pozycji
| tytuł: | An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain |
| autor: | Pawliński Rafał, Janeczko Krzysztof 
|
| tytuł czasopisma: | Brain Research |
| tom: | 773 |
| numer: | 1-2 |
| data wydania: | 1997 |
| strony: | 231-234 |
| ISSN: |
0006-8993 |
| eISSN: |
1872-6240 |
| DOI: | |
| język: | angielski |
| język czasopisma: | angielski |
| abstrakt w j. dokumentu: | Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain. |
| wydział:instytut/zakład/katedra: | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii |
| typ: | artykuł w czasopiśmie |
| podtyp: | inne publikacje |
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