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An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
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An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
Bibliographic description
| title: | An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain |
| author: | Pawliński Rafał, Janeczko Krzysztof 
|
| journal title: | Brain Research |
| volume: | 773 |
| issue: | 1-2 |
| date of publication : | 1997 |
| pages: | 231-234 |
| ISSN: |
0006-8993 |
| eISSN: |
1872-6240 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in other languages: | Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain. |
| affiliation: | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii |
| type: | journal article |
| subtype: | other documents |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
