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An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain.
cris.lastimport.scopus | 2024-04-24T04:37:47Z | |
cris.lastimport.wos | 2024-04-09T19:13:51Z | |
dc.abstract.other | Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain. | pl |
dc.affiliation | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii | pl |
dc.contributor.author | Pawliński, Rafał | pl |
dc.contributor.author | Janeczko, Krzysztof - 128444 | pl |
dc.date.accessioned | 2016-09-28T09:50:25Z | |
dc.date.available | 2016-09-28T09:50:25Z | |
dc.date.issued | 1997 | pl |
dc.description.number | 1-2 | pl |
dc.description.physical | 231-234 | pl |
dc.description.volume | 773 | pl |
dc.identifier.doi | 10.1016/S0006-8993(97)01024-X | pl |
dc.identifier.eissn | 1872-6240 | pl |
dc.identifier.issn | 0006-8993 | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/30905 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights.licence | bez licencji | |
dc.subtype | OtherDocuments | pl |
dc.title | An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain | pl |
dc.title.journal | Brain Research | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |