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Spatially resolved macromolecular orientation in biological tissues using FT-IR imaging
molecular orientation
collagen
linear polarization
FT-IR imaging
hermans function
Fourier-transform infrared spectroscopy (FT-IR) in combination with machine learning and chemometrics is an intensively developed, powerful tool for investigation of tissue biochemical composition with simultaneous microscopic visualization. This nondestructive, information rich and label-free technique has been successfully applied in cancer diagnostics. During the development of a disease or inflammatory processes, not only the chemical composition of tissues changes, but also their spatial organization. FT-IR imaging with linear polarization can provide new and useful information about chemically-specific orientation of macromolecules. Here, we present results of spatial macromolecular orientation in human, pancreatic tissue using four-polarization FT-IR method. Despite the much more complex chemical structure of tissue compared to artificial materials such as fibrillar polymers, the obtained orientations of biomolecules in tissue agreed with theoretical prediction.
cris.lastimport.scopus | 2024-04-07T18:04:12Z | |
cris.lastimport.wos | 2024-04-10T00:26:44Z | |
dc.abstract.en | Fourier-transform infrared spectroscopy (FT-IR) in combination with machine learning and chemometrics is an intensively developed, powerful tool for investigation of tissue biochemical composition with simultaneous microscopic visualization. This nondestructive, information rich and label-free technique has been successfully applied in cancer diagnostics. During the development of a disease or inflammatory processes, not only the chemical composition of tissues changes, but also their spatial organization. FT-IR imaging with linear polarization can provide new and useful information about chemically-specific orientation of macromolecules. Here, we present results of spatial macromolecular orientation in human, pancreatic tissue using four-polarization FT-IR method. Despite the much more complex chemical structure of tissue compared to artificial materials such as fibrillar polymers, the obtained orientations of biomolecules in tissue agreed with theoretical prediction. | pl |
dc.affiliation | Pion Prorektora ds. badań naukowych : Narodowe Centrum Promieniowania Synchrotronowego SOLARIS | pl |
dc.contributor.author | Kosowska, Karolina - 442738 | pl |
dc.contributor.author | Kozioł, Paulina - 430270 | pl |
dc.contributor.author | Liberda, Danuta - 226686 | pl |
dc.contributor.author | Wróbel, Tomasz - 107687 | pl |
dc.date.accessioned | 2023-01-02T14:26:39Z | |
dc.date.available | 2023-01-02T14:26:39Z | |
dc.date.issued | 2021 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 3 | pl |
dc.identifier.articleid | 100013 | pl |
dc.identifier.doi | 10.1016/j.clispe.2021.100013 | pl |
dc.identifier.eissn | 2666-0547 | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/305467 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa | * |
dc.rights.licence | CC-BY | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/legalcode.pl | * |
dc.share.type | otwarte czasopismo | |
dc.subject.en | molecular orientation | pl |
dc.subject.en | collagen | pl |
dc.subject.en | linear polarization | pl |
dc.subject.en | FT-IR imaging | pl |
dc.subject.en | hermans function | pl |
dc.subtype | Article | pl |
dc.title | Spatially resolved macromolecular orientation in biological tissues using FT-IR imaging | pl |
dc.title.journal | Clinical Spectroscopy | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |