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Surface modification of pollen-shape carriers for dry powder inhalation through surface etching

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Surface modification of pollen-shape carriers for dry powder inhalation through surface etching

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dc.contributor.author Nguyen, Thi Quynh Ngoc pl
dc.contributor.author Giam, Hung Loong pl
dc.contributor.author Wang, Yabo pl
dc.contributor.author Pacławski, Adam pl
dc.contributor.author Szlęk, Jakub [SAP20002579] pl
dc.contributor.author Mendyk, Aleksander [SAP20001709] pl
dc.contributor.author Shao, Yu-Hsuan pl
dc.contributor.author Lau, Raymond pl
dc.date.accessioned 2015-02-11T13:42:55Z
dc.date.available 2015-02-11T13:42:55Z
dc.date.issued 2014 pl
dc.identifier.issn 0888-5885 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3027
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Surface modification of pollen-shape carriers for dry powder inhalation through surface etching pl
dc.type JournalArticle pl
dc.description.physical 19943-19950 pl
dc.abstract.en Surface modification of pollen-shape hydroxyapatite (HA) carriers is achieved using surface etching technique. Characterization of HA carriers before and after etching are performed by scanning electron microscopy (SEM), Carr’s compressibility index (CI), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Four surface etching temperatures are tested but only the particles etched at 40 and 50 °C are found satisfactory. Proper surface etching allows a reduction of the petal-like structure on the particle surface and improves the crystallinity of the particles. While the reduction of petal-like structure decreases the emitted dose (ED) of the drug particles, an increase in fine particle fraction (FPF) can be attained owing to the improvement in drug liberation. An increase in the air flow rate, however, decreases the significance of particle surface morphology and the difference in FPF among the use of different carrier particles diminishes. Surface etching technique is found to have good potential as an economical process to improve dry powder inhalation efficiency through surface modification. pl
dc.description.volume 53 pl
dc.description.number 51 pl
dc.identifier.doi 10.1021/ie502980k pl
dc.identifier.eissn 1520-5045 pl
dc.title.journal Industrial & Engineering Chemistry Research pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji pl
dc.subtype Article pl
dc.cm.id 69993
.pointsMNiSW [2014 A]: 35


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