Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients

2022
journal article
article
3
cris.lastimport.wos2024-04-10T00:30:17Z
dc.abstract.enIntroduction: Systemic lupus erythematosus (SLE) is characterized by early atherothrombosis. Pulse wave velocity (PWV) is a promising tool for the diagnosis of early vascular remodelling and initial atherosclerotic plaque formation. Our objective was to evaluate PWV and its relationship with coronary atherosclerosis and thrombotic biomarkers in patients with SLE. Material and methods: In 26 patients with SLE with stable clinical conditions, mean age of 39.1 ±11.7 years and without a history of coronary artery disease, multidetector computed tomography (MDCT)-based coronary calcium scoring (CACS) was performed and PWV measured. Laboratory evaluation included serum levels of anticardiolipin and anti-β2-glycoprotein antibodies (anti-β2-GPI), lupus anticoagulant (LA), D-dimers, thrombin–antithrombin complexes (TAT), and von Willebrand factor (vWF). Results: Multidetector computed tomography revealed coronary calcifications in 8 (30.8%) patients and the median CACS was 52.4 HU (range 2–843.2). The mean PWV was 9.0 ±3.2 m/s and was higher in patients aged > 50 years (+33.7% vs. < 50 years), those with positive LA (+28.2% vs. LA negative), TAT ≥ 10 µg/l (+18.1% vs. < 10 µg/l), vWF ≥ 200 IU/dl (+51.8% vs. < 200 IU/dl) and with coronary atherosclerosis (CACS > 0; +21.4% vs. CACS = 0). In contrast, the duration of the disease, D-dimers, anticardiolipin, and anti-β2-GPI antibodies did not influence PWV. In the group without atherosclerosis (CACS = 0, n =18), patients with vWF ≥ 200 IU/dl had a 19.3% higher PWV compared to the rest. Conclusions: In patients with SLE, PWV was associated with the presence of coronary atherosclerotic lesions in MDCT. Furthermore, arterial stiffness was higher in patients with markers of endothelial dysfunction and a prothrombotic state, suggesting their contribution to the early stages of arterial remodelling in SLE.
dc.affiliationWydział Lekarski : Zakład Farmakologiipl
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.cm.date2022-08-23T22:16:15Z
dc.cm.id109243pl
dc.cm.idOmegaUJCM49873a778ee34839875fa8bbc67e168epl
dc.contributor.authorDziedzic-Oleksy, Hannapl
dc.contributor.authorMazurek, Adam - 141450 pl
dc.contributor.authorBugała, Kamilpl
dc.contributor.authorPerricone, Carlopl
dc.contributor.authorDrabik, Leszek - 159322 pl
dc.contributor.authorPłazak, Wojciech - 200500 pl
dc.date.accession2022-08-23pl
dc.date.accessioned2022-08-23T22:16:15Z
dc.date.available2022-08-23T22:16:15Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical165-172pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume60pl
dc.identifier.doi10.5114/reum.2022.117836pl
dc.identifier.eissn2084-9834pl
dc.identifier.issn0034-6233pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/298391
dc.identifier.weblinkhttps://www.termedia.pl/Arterial-stiffness-and-atherosclerosis-in-systemic-lupus-erythematosus-patients,18,47401,1,1.htmlpl
dc.languageengpl
dc.language.containerpolpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.typeOtwarte czasopismo
dc.subject.ensystemic lupus erythematosus
dc.subject.enautoimmune diseases
dc.subject.enpulse wave velocity
dc.subject.encoronary calcification
dc.subtypeArticlepl
dc.titleArterial stiffness and atherosclerosis in systemic lupus erythematosus patientspl
dc.title.journalReumatologia/Rheumatologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T00:30:17Z
dc.abstract.en
Introduction: Systemic lupus erythematosus (SLE) is characterized by early atherothrombosis. Pulse wave velocity (PWV) is a promising tool for the diagnosis of early vascular remodelling and initial atherosclerotic plaque formation. Our objective was to evaluate PWV and its relationship with coronary atherosclerosis and thrombotic biomarkers in patients with SLE. Material and methods: In 26 patients with SLE with stable clinical conditions, mean age of 39.1 ±11.7 years and without a history of coronary artery disease, multidetector computed tomography (MDCT)-based coronary calcium scoring (CACS) was performed and PWV measured. Laboratory evaluation included serum levels of anticardiolipin and anti-β2-glycoprotein antibodies (anti-β2-GPI), lupus anticoagulant (LA), D-dimers, thrombin–antithrombin complexes (TAT), and von Willebrand factor (vWF). Results: Multidetector computed tomography revealed coronary calcifications in 8 (30.8%) patients and the median CACS was 52.4 HU (range 2–843.2). The mean PWV was 9.0 ±3.2 m/s and was higher in patients aged > 50 years (+33.7% vs. < 50 years), those with positive LA (+28.2% vs. LA negative), TAT ≥ 10 µg/l (+18.1% vs. < 10 µg/l), vWF ≥ 200 IU/dl (+51.8% vs. < 200 IU/dl) and with coronary atherosclerosis (CACS > 0; +21.4% vs. CACS = 0). In contrast, the duration of the disease, D-dimers, anticardiolipin, and anti-β2-GPI antibodies did not influence PWV. In the group without atherosclerosis (CACS = 0, n =18), patients with vWF ≥ 200 IU/dl had a 19.3% higher PWV compared to the rest. Conclusions: In patients with SLE, PWV was associated with the presence of coronary atherosclerotic lesions in MDCT. Furthermore, arterial stiffness was higher in patients with markers of endothelial dysfunction and a prothrombotic state, suggesting their contribution to the early stages of arterial remodelling in SLE.
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.cm.date
2022-08-23T22:16:15Z
dc.cm.idpl
109243
dc.cm.idOmegapl
UJCM49873a778ee34839875fa8bbc67e168e
dc.contributor.authorpl
Dziedzic-Oleksy, Hanna
dc.contributor.authorpl
Mazurek, Adam - 141450
dc.contributor.authorpl
Bugała, Kamil
dc.contributor.authorpl
Perricone, Carlo
dc.contributor.authorpl
Drabik, Leszek - 159322
dc.contributor.authorpl
Płazak, Wojciech - 200500
dc.date.accessionpl
2022-08-23
dc.date.accessioned
2022-08-23T22:16:15Z
dc.date.available
2022-08-23T22:16:15Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
165-172
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
60
dc.identifier.doipl
10.5114/reum.2022.117836
dc.identifier.eissnpl
2084-9834
dc.identifier.issnpl
0034-6233
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/298391
dc.identifier.weblinkpl
https://www.termedia.pl/Arterial-stiffness-and-atherosclerosis-in-systemic-lupus-erythematosus-patients,18,47401,1,1.html
dc.languagepl
eng
dc.language.containerpl
pol
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
Otwarte czasopismo
dc.subject.en
systemic lupus erythematosus
dc.subject.en
autoimmune diseases
dc.subject.en
pulse wave velocity
dc.subject.en
coronary calcification
dc.subtypepl
Article
dc.titlepl
Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients
dc.title.journalpl
Reumatologia/Rheumatology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
5
Views per month