Preparation of solid self-emulsifying drug delivery systems using magnesium aluminometasilicates and fluid-bed coating process

2014
journal article
article
29
cris.lastimport.wos2024-04-09T20:28:36Z
dc.abstract.enSolid lipid-based drug delivery systems combine the advantages of solid dosage forms and the solubilizing potential of lipophilic vehicles. In spite of the fact that many methods were proposed for the solidification of liquid lipid formulations, there is no data on the application of the fluid-bed coating technique to impregnate porous pellets, containing magnesium aluminometasilicates with liquid self-emulsifying formulations. Moreover, the functionality of magnesium aluminometasilicates to form porous pellets by the extrusion/spheronization process has not been studied so far. Therefore, the aim of the present work was to determine if magnesium aluminometasilicates could be incorporated into pellets in the extrusion/spheronization process and then to examine if such pellets may be used as solid cores for the conversion of liquid SEDDS into solid SEDDS (S-SEDDS) in the fluid-bed coating process. To achieve these goals, three grades of Neusilin namely SG2, US2 and NS2N were combined with MCC in three wt.% ratios i.e.: 30+70, 50+50, or 70+30. The results showed that the pellets whose matrix was composed of Neusilin SG2 had the highest porosity and the best mechanical resistance. The fluid-bed coating method was found suitable for the impregnation of the placebo pellets with liquid SEDDS, containing ibuprofen as an insoluble model drug. The amount of SEDDS adsorbed on the surface of pellets with silicates was from eight to fourteen times higher as compared to pellets without silicates. The morphology, diameter and circularity of pellets before and after the fluid-bed coating process was examined by scanning electron microscopy (SEM) and the automated particle characterization system (Morphologi G3). The pellets containing Neusilin SG2 had twice as high mechanical resistance as the pellets with Neusilin US2 or Neusilin NS2N, and they were suitable for fluid-bed processing. Dissolution studies showed that from the formulation composed of 70 wt.% of Neusilin SG2 after 45 min, more than 75% of ibuprofen was dissolved in water and after 30 min, more than 80% of ibuprofen was dissolved in the phosphate buffer. Similar results were obtained for S-SEDDS containing 70 wt.% of Neusilin US2. The sustained release of ibuprofen was found if 30 wt.% of Neusilin US2, 30–50% of Neusilin SG2, or 50–70 wt.% of Neusilin NS2N was incorporated into the matrix of pellets.pl
dc.affiliationWydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacjipl
dc.cm.id69996
dc.contributor.authorKrupa, Anna - 130450 pl
dc.contributor.authorJachowicz, Renata - 129780 pl
dc.contributor.authorKurek, Mateusz - 140456 pl
dc.contributor.authorKwiecień, Magdalenapl
dc.contributor.authorFigiel, Wiesławpl
dc.date.accessioned2015-02-10T09:18:50Z
dc.date.available2015-02-10T09:18:50Z
dc.date.issued2014pl
dc.description.physical329-339pl
dc.description.volume266pl
dc.identifier.doi10.1016/j.powtec.2014.06.043pl
dc.identifier.eissn1873-328Xpl
dc.identifier.issn0032-5910pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2950
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.uri*
dc.subject.enfluid-bed coatingpl
dc.subject.enmagnesium aluminometasilicatepl
dc.subject.enpelletpl
dc.subject.enextrusion/spheronizationpl
dc.subject.enS-SEDDSpl
dc.subject.enibuprofenpl
dc.subtypeArticlepl
dc.titlePreparation of solid self-emulsifying drug delivery systems using magnesium aluminometasilicates and fluid-bed coating processpl
dc.title.journalPowder Technologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T20:28:36Z
dc.abstract.enpl
Solid lipid-based drug delivery systems combine the advantages of solid dosage forms and the solubilizing potential of lipophilic vehicles. In spite of the fact that many methods were proposed for the solidification of liquid lipid formulations, there is no data on the application of the fluid-bed coating technique to impregnate porous pellets, containing magnesium aluminometasilicates with liquid self-emulsifying formulations. Moreover, the functionality of magnesium aluminometasilicates to form porous pellets by the extrusion/spheronization process has not been studied so far. Therefore, the aim of the present work was to determine if magnesium aluminometasilicates could be incorporated into pellets in the extrusion/spheronization process and then to examine if such pellets may be used as solid cores for the conversion of liquid SEDDS into solid SEDDS (S-SEDDS) in the fluid-bed coating process. To achieve these goals, three grades of Neusilin namely SG2, US2 and NS2N were combined with MCC in three wt.% ratios i.e.: 30+70, 50+50, or 70+30. The results showed that the pellets whose matrix was composed of Neusilin SG2 had the highest porosity and the best mechanical resistance. The fluid-bed coating method was found suitable for the impregnation of the placebo pellets with liquid SEDDS, containing ibuprofen as an insoluble model drug. The amount of SEDDS adsorbed on the surface of pellets with silicates was from eight to fourteen times higher as compared to pellets without silicates. The morphology, diameter and circularity of pellets before and after the fluid-bed coating process was examined by scanning electron microscopy (SEM) and the automated particle characterization system (Morphologi G3). The pellets containing Neusilin SG2 had twice as high mechanical resistance as the pellets with Neusilin US2 or Neusilin NS2N, and they were suitable for fluid-bed processing. Dissolution studies showed that from the formulation composed of 70 wt.% of Neusilin SG2 after 45 min, more than 75% of ibuprofen was dissolved in water and after 30 min, more than 80% of ibuprofen was dissolved in the phosphate buffer. Similar results were obtained for S-SEDDS containing 70 wt.% of Neusilin US2. The sustained release of ibuprofen was found if 30 wt.% of Neusilin US2, 30–50% of Neusilin SG2, or 50–70 wt.% of Neusilin NS2N was incorporated into the matrix of pellets.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji
dc.cm.id
69996
dc.contributor.authorpl
Krupa, Anna - 130450
dc.contributor.authorpl
Jachowicz, Renata - 129780
dc.contributor.authorpl
Kurek, Mateusz - 140456
dc.contributor.authorpl
Kwiecień, Magdalena
dc.contributor.authorpl
Figiel, Wiesław
dc.date.accessioned
2015-02-10T09:18:50Z
dc.date.available
2015-02-10T09:18:50Z
dc.date.issuedpl
2014
dc.description.physicalpl
329-339
dc.description.volumepl
266
dc.identifier.doipl
10.1016/j.powtec.2014.06.043
dc.identifier.eissnpl
1873-328X
dc.identifier.issnpl
0032-5910
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/2950
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.uri*
dc.subject.enpl
fluid-bed coating
dc.subject.enpl
magnesium aluminometasilicate
dc.subject.enpl
pellet
dc.subject.enpl
extrusion/spheronization
dc.subject.enpl
S-SEDDS
dc.subject.enpl
ibuprofen
dc.subtypepl
Article
dc.titlepl
Preparation of solid self-emulsifying drug delivery systems using magnesium aluminometasilicates and fluid-bed coating process
dc.title.journalpl
Powder Technology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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