A single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristics

2022
journal article
article
13
cris.lastimport.wos2024-04-09T21:09:16Z
dc.abstract.enBackground: Left bundle branch area pacing (LBBAP) has recently been introduced as a physiological pacing technique with synchronous left ventricular activation. It was our aim to evaluate the feasibility and learning curve of the technique, as well as the electrical characteristics of LBBAP. Methods and results: LBBAP was attempted in 80 consecutive patients and electrocardiographic characteristics were evaluated during intrinsic rhythm, right ventricular septum pacing (RVSP) and LBBAP. Permanent lead implantation was successful in 77 of 80 patients (96%). LBBAP lead implantation time and fluoroscopy time shortened significantly from 33 ± 16 and 21 ± 13 min to 17 ± 5 and 12 ± 7 min, respectively, from the first 20 to the last 20 patients. Left bundle branch (LBB) capture was achieved in 54 of 80 patients (68%). In 36 of 45 patients (80%) with intact atrioventricular conduction and narrow QRS, an LBB potential (LBBpot) was present with an LBBpot to onset of QRS interval of 22 ± 6 ms. QRS duration increased significantly more during RVSP (141 ± 20 ms) than during LBBAP (125 ± 19 ms), compared to 130 ± 30 ms without pacing. An even clearer difference was observed for QRS area, which increased significantly more during RVSP (from 32 ± 16 µVs to 73 ± 20 µVs) than during LBBAP (41 ± 15 µVs). QRS area was significantly smaller in patients with LBB capture compared to patients without LBB capture (43 ± 18 µVs vs 54 ± 21 µVs, respectively). In patients with LBB capture (n = 54), the interval from the pacing stimulus to R‑wave peak time in lead V6 was significantly shorter than in patients without LBB capture (75 ± 14 vs 88 ± 9 ms, respectively). Conclusion: LBBAP is a safe and feasible technique, with a clear learning curve that seems to flatten after 40–60 implantations. LBB capture is achieved in two-thirds of patients. Compared to RVSP, LBBAP largely maintains ventricular electrical synchrony at a level close to intrinsic (narrow QRS) rhythm.
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.cm.date2022-06-06T03:12:31Z
dc.cm.id108270pl
dc.cm.idOmegaUJCM9dbd0c7b057b4932bb4d565c42868bc9pl
dc.contributor.authorHeckman, L.I.B.pl
dc.contributor.authorLuermans, J.G.L.M.pl
dc.contributor.authorJastrzębski, Marek - 255841 pl
dc.contributor.authorWeijs, B.pl
dc.contributor.authorvan Stipdonk, A.M.W.pl
dc.contributor.authorWestra, S.pl
dc.contributor.authorden Uijl, D.pl
dc.contributor.authorLinz, D.pl
dc.contributor.authorMafi-Rad, M.pl
dc.contributor.authorPrinzen, F.W.pl
dc.contributor.authorVernooy, K.pl
dc.date.accession2022-06-05pl
dc.date.accessioned2022-06-06T03:12:31Z
dc.date.available2022-06-06T03:12:31Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number5pl
dc.description.physical249-257pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume30pl
dc.identifier.doi10.1007/s12471-022-01679-7pl
dc.identifier.eissn1876-6250pl
dc.identifier.issn1568-5888pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/292686
dc.identifier.weblinkhttps://link.springer.com/article/10.1007/s12471-022-01679-7pl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.typeOtwarte czasopismo
dc.subject.enleft bundle branch pacing
dc.subject.enbradycardia pacing
dc.subject.encardiac resynchronisation therapy
dc.subtypeArticlepl
dc.titleA single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristicspl
dc.title.journalNetherlands Heart Journalpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:09:16Z
dc.abstract.en
Background: Left bundle branch area pacing (LBBAP) has recently been introduced as a physiological pacing technique with synchronous left ventricular activation. It was our aim to evaluate the feasibility and learning curve of the technique, as well as the electrical characteristics of LBBAP. Methods and results: LBBAP was attempted in 80 consecutive patients and electrocardiographic characteristics were evaluated during intrinsic rhythm, right ventricular septum pacing (RVSP) and LBBAP. Permanent lead implantation was successful in 77 of 80 patients (96%). LBBAP lead implantation time and fluoroscopy time shortened significantly from 33 ± 16 and 21 ± 13 min to 17 ± 5 and 12 ± 7 min, respectively, from the first 20 to the last 20 patients. Left bundle branch (LBB) capture was achieved in 54 of 80 patients (68%). In 36 of 45 patients (80%) with intact atrioventricular conduction and narrow QRS, an LBB potential (LBBpot) was present with an LBBpot to onset of QRS interval of 22 ± 6 ms. QRS duration increased significantly more during RVSP (141 ± 20 ms) than during LBBAP (125 ± 19 ms), compared to 130 ± 30 ms without pacing. An even clearer difference was observed for QRS area, which increased significantly more during RVSP (from 32 ± 16 µVs to 73 ± 20 µVs) than during LBBAP (41 ± 15 µVs). QRS area was significantly smaller in patients with LBB capture compared to patients without LBB capture (43 ± 18 µVs vs 54 ± 21 µVs, respectively). In patients with LBB capture (n = 54), the interval from the pacing stimulus to R‑wave peak time in lead V6 was significantly shorter than in patients without LBB capture (75 ± 14 vs 88 ± 9 ms, respectively). Conclusion: LBBAP is a safe and feasible technique, with a clear learning curve that seems to flatten after 40–60 implantations. LBB capture is achieved in two-thirds of patients. Compared to RVSP, LBBAP largely maintains ventricular electrical synchrony at a level close to intrinsic (narrow QRS) rhythm.
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.cm.date
2022-06-06T03:12:31Z
dc.cm.idpl
108270
dc.cm.idOmegapl
UJCM9dbd0c7b057b4932bb4d565c42868bc9
dc.contributor.authorpl
Heckman, L.I.B.
dc.contributor.authorpl
Luermans, J.G.L.M.
dc.contributor.authorpl
Jastrzębski, Marek - 255841
dc.contributor.authorpl
Weijs, B.
dc.contributor.authorpl
van Stipdonk, A.M.W.
dc.contributor.authorpl
Westra, S.
dc.contributor.authorpl
den Uijl, D.
dc.contributor.authorpl
Linz, D.
dc.contributor.authorpl
Mafi-Rad, M.
dc.contributor.authorpl
Prinzen, F.W.
dc.contributor.authorpl
Vernooy, K.
dc.date.accessionpl
2022-06-05
dc.date.accessioned
2022-06-06T03:12:31Z
dc.date.available
2022-06-06T03:12:31Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
5
dc.description.physicalpl
249-257
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
30
dc.identifier.doipl
10.1007/s12471-022-01679-7
dc.identifier.eissnpl
1876-6250
dc.identifier.issnpl
1568-5888
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/292686
dc.identifier.weblinkpl
https://link.springer.com/article/10.1007/s12471-022-01679-7
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
Otwarte czasopismo
dc.subject.en
left bundle branch pacing
dc.subject.en
bradycardia pacing
dc.subject.en
cardiac resynchronisation therapy
dc.subtypepl
Article
dc.titlepl
A single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristics
dc.title.journalpl
Netherlands Heart Journal
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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