Low-cost, programmable infusion pump with bolus mode for in-vivo imaging

2021
journal article
article
6
cris.lastimport.wos2024-04-09T19:22:33Z
dc.abstract.enSyringe pumps are routinely used in biomedical imaging laboratories for delivering contrast agents and either infusing or injecting a precise amount of liquids. Commercial syringe pumps that are developed by specialized companies are expensive and only have standard functions, which often do not meet the requirements of individual experiments. In this paper, we demonstrate an open-source single syringe pump with the possibility of adapting to the needs of a researcher. The device that was designed, is controlled by an Arduino Leonardo, along with the stepper motor driver. For sending commands and receiving the current plunger position, a C# software was developed with serial communication via USB. Additionally, the 3D models were made in a universal way, which allows for the use of any syringe size. An example of the application of the syringe pump for biomedical applications was demonstrated using electron resonance imaging (ERI). The single syringe pump tests were demonstrated by simulating the filling of a particular volume inside the resonator. This example reflects the clearance process after an intravascular (I.V) drug administration in the murine model. The experiments were performed on an ERI TM 600 tomograph. The results confirmed that the designed syringe pump allowed for controlling the infusion speed and injected volume. Moreover, we present a user-friendly and opensource graphical interface that is a low-cost alternative for commercial devices.pl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologiipl
dc.contributor.authorKujawa, Maciejpl
dc.contributor.authorMotała, Szymonpl
dc.contributor.authorGonet, Michał - 164923 pl
dc.contributor.authorPietrzyk, Rafałpl
dc.contributor.authorCzechowski, Tomaszpl
dc.contributor.authorBaranowski, Mikołajpl
dc.date.accessioned2021-10-22T11:44:59Z
dc.date.available2021-10-22T11:44:59Z
dc.date.issued2021pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.versionostateczna wersja wydawcy
dc.description.volume9pl
dc.identifier.articleide00194pl
dc.identifier.doi10.1016/j.ohx.2021.e00194pl
dc.identifier.eissn2468-0672pl
dc.identifier.projectROD UJ / Opl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/281375
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.ensyringe pumppl
dc.subject.enelectron resonance imaging (ERI)pl
dc.subject.ensimulation of physiological processespl
dc.subject.enArduinopl
dc.subject.en3D printingpl
dc.subtypeArticlepl
dc.titleLow-cost, programmable infusion pump with bolus mode for in-vivo imagingpl
dc.title.journalHardwareXpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T19:22:33Z
dc.abstract.enpl
Syringe pumps are routinely used in biomedical imaging laboratories for delivering contrast agents and either infusing or injecting a precise amount of liquids. Commercial syringe pumps that are developed by specialized companies are expensive and only have standard functions, which often do not meet the requirements of individual experiments. In this paper, we demonstrate an open-source single syringe pump with the possibility of adapting to the needs of a researcher. The device that was designed, is controlled by an Arduino Leonardo, along with the stepper motor driver. For sending commands and receiving the current plunger position, a C# software was developed with serial communication via USB. Additionally, the 3D models were made in a universal way, which allows for the use of any syringe size. An example of the application of the syringe pump for biomedical applications was demonstrated using electron resonance imaging (ERI). The single syringe pump tests were demonstrated by simulating the filling of a particular volume inside the resonator. This example reflects the clearance process after an intravascular (I.V) drug administration in the murine model. The experiments were performed on an ERI TM 600 tomograph. The results confirmed that the designed syringe pump allowed for controlling the infusion speed and injected volume. Moreover, we present a user-friendly and opensource graphical interface that is a low-cost alternative for commercial devices.
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii
dc.contributor.authorpl
Kujawa, Maciej
dc.contributor.authorpl
Motała, Szymon
dc.contributor.authorpl
Gonet, Michał - 164923
dc.contributor.authorpl
Pietrzyk, Rafał
dc.contributor.authorpl
Czechowski, Tomasz
dc.contributor.authorpl
Baranowski, Mikołaj
dc.date.accessioned
2021-10-22T11:44:59Z
dc.date.available
2021-10-22T11:44:59Z
dc.date.issuedpl
2021
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
9
dc.identifier.articleidpl
e00194
dc.identifier.doipl
10.1016/j.ohx.2021.e00194
dc.identifier.eissnpl
2468-0672
dc.identifier.projectpl
ROD UJ / O
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/281375
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
syringe pump
dc.subject.enpl
electron resonance imaging (ERI)
dc.subject.enpl
simulation of physiological processes
dc.subject.enpl
Arduino
dc.subject.enpl
3D printing
dc.subtypepl
Article
dc.titlepl
Low-cost, programmable infusion pump with bolus mode for in-vivo imaging
dc.title.journalpl
HardwareX
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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