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The role of complement component C3 activation in the clinical presentation and prognosis of IgA nephropathy - a national study in children
Journal
Journal of Clinical Medicine
140
Author
Mizerska-Wasiak Małgorzata
Such-Gruchot Agnieszka
Cichoń-Kawa Karolina
Turczyn Agnieszka
Małdyk Jadwiga
Volume
10
Issue
19
Article ID
4405
ISSN
2077-0383
eISSN
2077-0383
Keywords in English
IgA nephropathy
complement C3
children
Access date
2022-02-01
Language
English
Journal language
English
Abstract in English
The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children.
Affiliation
Wydział Lekarski : Instytut Pediatrii
Scopus© citations
8
| dc.abstract.en | The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children. | |
| dc.affiliation | Wydział Lekarski : Instytut Pediatrii | pl |
| dc.cm.date | 2021-10-15 | |
| dc.cm.id | 105936 | |
| dc.cm.idOmega | UJCM404c4d4732f44d378bce0488f9c3fc3c | pl |
| dc.contributor.author | Mizerska-Wasiak, Małgorzata | pl |
| dc.contributor.author | Such-Gruchot, Agnieszka | pl |
| dc.contributor.author | Cichoń-Kawa, Karolina | pl |
| dc.contributor.author | Turczyn, Agnieszka | pl |
| dc.contributor.author | Małdyk, Jadwiga | pl |
| dc.contributor.author | Miklaszewska, Monika - 173942 | pl |
| dc.contributor.author | Drożdż, Dorota - 129246 | pl |
| dc.contributor.author | Firszt-Adamczyk, Agnieszka | pl |
| dc.contributor.author | Stankiewicz, Roman | pl |
| dc.contributor.author | Rybi-Szumińska, Agnieszka | pl |
| dc.contributor.author | Wasilewska, Anna | pl |
| dc.contributor.author | Szczepańska, Maria | pl |
| dc.contributor.author | Bieniaś, Beata | pl |
| dc.contributor.author | Sikora, Przemysław | pl |
| dc.contributor.author | Pukajło-Marczyk, Agnieszka | pl |
| dc.contributor.author | Zwolińska, Danuta | pl |
| dc.contributor.author | Pawlak-Bratkowska, Monika | pl |
| dc.contributor.author | Tkaczyk, Marcin | pl |
| dc.contributor.author | Zachwieja, Jacek | pl |
| dc.contributor.author | Drożyńska-Duklas, Magdalena | pl |
| dc.contributor.author | Żurowska, Aleksandra | pl |
| dc.contributor.author | Gadomska-Prokop, Katarzyna | pl |
| dc.contributor.author | Grenda, Ryszard | pl |
| dc.contributor.author | Pańczyk-Tomaszewska, Małgorzata | pl |
| dc.date.accession | 2022-02-01 | pl |
| dc.date.accessioned | 2021-10-15T09:01:38Z | |
| dc.date.available | 2021-10-15T09:01:38Z | |
| dc.date.issued | 2021 | pl |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.number | 19 | pl |
| dc.description.points | 140 | |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 10 | pl |
| dc.identifier.articleid | 4405 | pl |
| dc.identifier.doi | 10.3390/jcm10194405 | pl |
| dc.identifier.eissn | 2077-0383 | pl |
| dc.identifier.issn | 2077-0383 | pl |
| dc.identifier.project | ROD UJ / O | pl |
| dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/280643 | |
| dc.identifier.weblink | https://www.mdpi.com/2077-0383/10/19/4405 | pl |
| dc.language | eng | pl |
| dc.language.container | eng | pl |
| dc.pbn.affiliation | Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne | |
| dc.relation.uri | * | |
| dc.rights | Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa | |
| dc.rights.licence | CC-BY | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/legalcode.pl | |
| dc.share.type | Otwarte czasopismo | |
| dc.subject.en | IgA nephropathy | |
| dc.subject.en | complement C3 | |
| dc.subject.en | children | |
| dc.subtype | Article | pl |
| dc.title | The role of complement component C3 activation in the clinical presentation and prognosis of IgA nephropathy - a national study in children | pl |
| dc.title.journal | Journal of Clinical Medicine | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |
dc.abstract.en
The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children. dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii dc.cm.date
2021-10-15 dc.cm.id
105936 dc.cm.idOmegapl
UJCM404c4d4732f44d378bce0488f9c3fc3c dc.contributor.authorpl
Mizerska-Wasiak, Małgorzata dc.contributor.authorpl
Such-Gruchot, Agnieszka dc.contributor.authorpl
Cichoń-Kawa, Karolina dc.contributor.authorpl
Turczyn, Agnieszka dc.contributor.authorpl
Małdyk, Jadwiga dc.contributor.authorpl
Miklaszewska, Monika - 173942 dc.contributor.authorpl
Drożdż, Dorota - 129246 dc.contributor.authorpl
Firszt-Adamczyk, Agnieszka dc.contributor.authorpl
Stankiewicz, Roman dc.contributor.authorpl
Rybi-Szumińska, Agnieszka dc.contributor.authorpl
Wasilewska, Anna dc.contributor.authorpl
Szczepańska, Maria dc.contributor.authorpl
Bieniaś, Beata dc.contributor.authorpl
Sikora, Przemysław dc.contributor.authorpl
Pukajło-Marczyk, Agnieszka dc.contributor.authorpl
Zwolińska, Danuta dc.contributor.authorpl
Pawlak-Bratkowska, Monika dc.contributor.authorpl
Tkaczyk, Marcin dc.contributor.authorpl
Zachwieja, Jacek dc.contributor.authorpl
Drożyńska-Duklas, Magdalena dc.contributor.authorpl
Żurowska, Aleksandra dc.contributor.authorpl
Gadomska-Prokop, Katarzyna dc.contributor.authorpl
Grenda, Ryszard dc.contributor.authorpl
Pańczyk-Tomaszewska, Małgorzata dc.date.accessionpl
2022-02-01 dc.date.accessioned
2021-10-15T09:01:38Z dc.date.available
2021-10-15T09:01:38Z dc.date.issuedpl
2021 dc.date.openaccess
0 dc.description.accesstime
w momencie opublikowania dc.description.numberpl
19 dc.description.points
140 dc.description.version
ostateczna wersja wydawcy dc.description.volumepl
10 dc.identifier.articleidpl
4405 dc.identifier.doipl
10.3390/jcm10194405 dc.identifier.eissnpl
2077-0383 dc.identifier.issnpl
2077-0383 dc.identifier.projectpl
ROD UJ / O dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/280643 dc.identifier.weblinkpl
https://www.mdpi.com/2077-0383/10/19/4405 dc.languagepl
eng dc.language.containerpl
eng dc.pbn.affiliation
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne dc.relation.uri*
dc.rights
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa dc.rights.licence
CC-BY dc.rights.uri
http://creativecommons.org/licenses/by/4.0/legalcode.pl dc.share.type
Otwarte czasopismo dc.subject.en
IgA nephropathy dc.subject.en
complement C3 dc.subject.en
children dc.subtypepl
Article dc.titlepl
The role of complement component C3 activation in the clinical presentation and prognosis of IgA nephropathy - a national study in children dc.title.journalpl
Journal of Clinical Medicine dc.typepl
JournalArticle dspace.entity.type
Publication Affiliations
Wydział Lekarski
Miklaszewska, Monika
Drożdż, Dorota
No affiliation
Mizerska-Wasiak, Małgorzata
Such-Gruchot, Agnieszka
Cichoń-Kawa, Karolina
Turczyn, Agnieszka
Małdyk, Jadwiga
Firszt-Adamczyk, Agnieszka
Stankiewicz, Roman
Rybi-Szumińska, Agnieszka
Wasilewska, Anna
Szczepańska, Maria
Bieniaś, Beata
Sikora, Przemysław
Pukajło-Marczyk, Agnieszka
Zwolińska, Danuta
Pawlak-Bratkowska, Monika
Tkaczyk, Marcin
Zachwieja, Jacek
Drożyńska-Duklas, Magdalena
Żurowska, Aleksandra
Gadomska-Prokop, Katarzyna
Grenda, Ryszard
Pańczyk-Tomaszewska, Małgorzata
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