Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

2021
journal article
article
61
cris.lastimport.wos2024-04-09T23:11:39Z
dc.abstract.enThe ability to perform noninvasive and non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors. These have many disadvantages in terms of high cost, flexibility and limited portability as well as poor spatial and temporal resolution. In this work we demonstrate an alternative technique for detecting magnetic fields generated by the current from action potentials in living tissue using nitrogen vacancy centres in diamond. With 50 pT/$\sqrt{\text {Hz}}$Hzsensitivity, we show the first measurements of magnetic sensing from mammalian tissue with a diamond sensor using mouse muscle optogenetically activated with blue light. We show these proof of principle measurements can be performed in an ordinary, unshielded lab environment and that the signal can be easily recovered by digital signal processing techniques. Although as yet uncompetitive with probe electrophysiology in terms of sensitivity, we demonstrate the feasibility of sensing action potentials via magnetic field in mammals using a diamond quantum sensor, as a step towards microscopic imaging of electrical activity in a biological sample using nitrogen vacancy centres in diamond.pl
dc.affiliationWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiegopl
dc.contributor.authorWebb, James Lukepl
dc.contributor.authorTroise, Lucapl
dc.contributor.authorHansen, Nikolaj Wintherpl
dc.contributor.authorOlsson, Christofferpl
dc.contributor.authorWojciechowski, Adam - 139902 pl
dc.contributor.authorAchard, Jocelynpl
dc.contributor.authorBrinza, Ovidiupl
dc.contributor.authorStaacke, Robertpl
dc.contributor.authorKieschnick, Michaelpl
dc.contributor.authorMeijer, Janpl
dc.contributor.authorThielscher, Axelpl
dc.contributor.authorPerrier, Jean-Françoispl
dc.contributor.authorBerg-Sørensen, Kirstinepl
dc.contributor.authorHuck, Alexanderpl
dc.contributor.authorAndersen, Ulrik Lundpl
dc.date.accessioned2021-03-09T10:24:26Z
dc.date.available2021-03-09T10:24:26Z
dc.date.issued2021pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume11pl
dc.identifier.articleid2412pl
dc.identifier.doi10.1038/s41598-021-81828-xpl
dc.identifier.eissn2045-2322pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/266842
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk ścisłych i przyrodniczych : nauki fizycznepl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.source.integratorfalse
dc.subtypeArticlepl
dc.titleDetection of biological signals from a live mammalian muscle using an early stage diamond quantum sensorpl
dc.title.journalScientific Reportspl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T23:11:39Z
dc.abstract.enpl
The ability to perform noninvasive and non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors. These have many disadvantages in terms of high cost, flexibility and limited portability as well as poor spatial and temporal resolution. In this work we demonstrate an alternative technique for detecting magnetic fields generated by the current from action potentials in living tissue using nitrogen vacancy centres in diamond. With 50 pT/$\sqrt{\text {Hz}}$Hzsensitivity, we show the first measurements of magnetic sensing from mammalian tissue with a diamond sensor using mouse muscle optogenetically activated with blue light. We show these proof of principle measurements can be performed in an ordinary, unshielded lab environment and that the signal can be easily recovered by digital signal processing techniques. Although as yet uncompetitive with probe electrophysiology in terms of sensitivity, we demonstrate the feasibility of sensing action potentials via magnetic field in mammals using a diamond quantum sensor, as a step towards microscopic imaging of electrical activity in a biological sample using nitrogen vacancy centres in diamond.
dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
dc.contributor.authorpl
Webb, James Luke
dc.contributor.authorpl
Troise, Luca
dc.contributor.authorpl
Hansen, Nikolaj Winther
dc.contributor.authorpl
Olsson, Christoffer
dc.contributor.authorpl
Wojciechowski, Adam - 139902
dc.contributor.authorpl
Achard, Jocelyn
dc.contributor.authorpl
Brinza, Ovidiu
dc.contributor.authorpl
Staacke, Robert
dc.contributor.authorpl
Kieschnick, Michael
dc.contributor.authorpl
Meijer, Jan
dc.contributor.authorpl
Thielscher, Axel
dc.contributor.authorpl
Perrier, Jean-François
dc.contributor.authorpl
Berg-Sørensen, Kirstine
dc.contributor.authorpl
Huck, Alexander
dc.contributor.authorpl
Andersen, Ulrik Lund
dc.date.accessioned
2021-03-09T10:24:26Z
dc.date.available
2021-03-09T10:24:26Z
dc.date.issuedpl
2021
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
11
dc.identifier.articleidpl
2412
dc.identifier.doipl
10.1038/s41598-021-81828-x
dc.identifier.eissnpl
2045-2322
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/266842
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk ścisłych i przyrodniczych : nauki fizyczne
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.source.integrator
false
dc.subtypepl
Article
dc.titlepl
Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor
dc.title.journalpl
Scientific Reports
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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