Współistnienie choroby Ollier'a i nieziarniczego chłoniaka złośliwego u dziewięcioletniego chłopca

Bibliogr. s. 101

Ollier's disease (enchondromatosis, chondromatosis multiplex) is a rarely occurring affection classified as osteochondrodysplasia and characterized by ataxic, multifocal hypertrophy of the chondrus. Sarcomatous transformation appears in 25% o f those affected. There are no cases of a coexistence of Ollier's disease and non-Hodgkin's lymphoma reported in accessible articles. A 9-year-old boy with Ollier's disease diagnosed in the second year o f life was admitted to the Clinic of Pediatrics, Hematology, and Pediatric Oncology because of cervical, submandibular, inguinal, and left axillary lymph node enlargement. Status at admission was estimated as medium-severe. Laboratory findings were a mediocre state o f anemia, tricipher OB, and increased LDH activity. Chest radiogram showed upper mediastinum and right hilus extension. Diagnosis of non-Hodgkin's B-cell lymphoma was made from a specimen taken during mediastinoscopy. Chemotherapy according to the LMB-89 program was applied. The presence o f multiple chondromas was confirmed in the scapulas, left humerus, ribs, right ilium, and left femur. Imaging diagnostics revealed the malignant transformation of a chondroma in the left humerus. Histological examination of a specimen of the tumor confirmed non-granulomatous, lymphomatous proliferation in the primary pathological lesion. Despite intensive chemo- and radiotherapy, the child died in the 5th month of treatment.