Obrazy mammograficzne i sonomammograficzne raka sutka u pacjentek obciążonych genetycznie, w tym z wykrytą mutacją BRCA1

Bibliogr. s. 13

Background: Carriers o f the BRCA1 mutation have 50-80% increased risk o f breast cancer. Therefore it is necessary to perform screening examinations regularly, more frequently than in the normal population. We suggest beginning mammography at 35 years of age, which significantly increases the chance of early detection of the cancer. Material/Methods: A total of 293 women aged 20-60 years were analyzed. All the women were examined at the Hereditary Cancer Center. Mammography and sonomammography were performed on all patients. Mammograms of women who had undergone mastectomy were evaluated retrospectively. Results: Benign-like changes, such as dense cysts or fibroadenomas, in the carrier group of the BRCA1 gene mutation were found in 40.5% of the women. Dynamic growth of the tumor was symptomatic. In the remaining group of women, morphology o f the detected cancers revealed large, stagingdependent variability. Conclusion: On the basis of these findings we can conclude that cancer in women with the BRCA1 gene mutation can have a benign-like morphology, but with rapid tumor growth. Therefore all suspicious or atypical changes should be verified histopathologically.