Simple view

Full metadata view

Authors

Statistics

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells

2012
journal article
article
Journal
Anticancer Research
Author
Amaral Leonard

Spengler Gabriella

Martins Ana

Armada Ana

Handzlik Jadwiga
Show more
Volume
32
Number
7
Pages
2947-2957
ISSN
0250-7005
eISSN
1791-7530
Keywords in English

bacteria

cancer

multidrug resistance

efflux pumps

inhibition of efflux pumps

phenothiazines

chlorpromazine

thioridazine

hydantoins

phenytoin

SILA 421

SILA 409

trifluoromethyl ketones

review

URL
http://ar.iiarjournals.org/content/32/7/2947.full.pdf+html
Access date
2020-10-20
Remarks

Bibliogr. s. 2952-2957

Language
English
Journal language
English
Abstract in English

Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.

Affiliation
Wydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczych
dc.abstract.enBacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.pl
dc.affiliationWydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczychpl
dc.contributor.authorAmaral, Leonardpl
dc.contributor.authorSpengler, Gabriellapl
dc.contributor.authorMartins, Anapl
dc.contributor.authorArmada, Anapl
dc.contributor.authorHandzlik, Jadwiga - 129685 pl
dc.contributor.authorKieć-Kononowicz, Katarzyna - 130088 pl
dc.contributor.authorMolnar, Josephpl
dc.date.accession2020-10-20pl
dc.date.accessioned2020-10-20T08:27:25Z
dc.date.available2020-10-20T08:27:25Z
dc.date.issued2012pl
dc.date.openaccess24
dc.description.accesstimepo opublikowaniu
dc.description.additionalBibliogr. s. 2952-2957pl
dc.description.number7pl
dc.description.physical2947-2957pl
dc.description.publication1,42pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume32pl
dc.identifier.eissn1791-7530pl
dc.identifier.issn0250-7005pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/248417
dc.identifier.weblinkhttp://ar.iiarjournals.org/content/32/7/2947.full.pdf+htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsDozwolony użytek utworów chronionych*
dc.rights.licenceInna otwarta licencja
dc.rights.urihttp://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf*
dc.share.typeotwarte czasopismo
dc.source.integratorfalse
dc.subject.enbacteriapl
dc.subject.encancerpl
dc.subject.enmultidrug resistancepl
dc.subject.enefflux pumpspl
dc.subject.eninhibition of efflux pumpspl
dc.subject.enphenothiazinespl
dc.subject.enchlorpromazinepl
dc.subject.enthioridazinepl
dc.subject.enhydantoinspl
dc.subject.enphenytoinpl
dc.subject.enSILA 421pl
dc.subject.enSILA 409pl
dc.subject.entrifluoromethyl ketonespl
dc.subject.enreviewpl
dc.subtypeArticlepl
dc.titleInhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cellspl
dc.title.journalAnticancer Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczych
dc.contributor.authorpl
Amaral, Leonard
dc.contributor.authorpl
Spengler, Gabriella
dc.contributor.authorpl
Martins, Ana
dc.contributor.authorpl
Armada, Ana
dc.contributor.authorpl
Handzlik, Jadwiga - 129685
dc.contributor.authorpl
Kieć-Kononowicz, Katarzyna - 130088
dc.contributor.authorpl
Molnar, Joseph
dc.date.accessionpl
2020-10-20
dc.date.accessioned
2020-10-20T08:27:25Z
dc.date.available
2020-10-20T08:27:25Z
dc.date.issuedpl
2012
dc.date.openaccess
24
dc.description.accesstime
po opublikowaniu
dc.description.additionalpl
Bibliogr. s. 2952-2957
dc.description.numberpl
7
dc.description.physicalpl
2947-2957
dc.description.publicationpl
1,42
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
32
dc.identifier.eissnpl
1791-7530
dc.identifier.issnpl
0250-7005
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/248417
dc.identifier.weblinkpl
http://ar.iiarjournals.org/content/32/7/2947.full.pdf+html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dozwolony użytek utworów chronionych
dc.rights.licence
Inna otwarta licencja
dc.rights.uri*
http://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf
dc.share.type
otwarte czasopismo
dc.source.integrator
false
dc.subject.enpl
bacteria
dc.subject.enpl
cancer
dc.subject.enpl
multidrug resistance
dc.subject.enpl
efflux pumps
dc.subject.enpl
inhibition of efflux pumps
dc.subject.enpl
phenothiazines
dc.subject.enpl
chlorpromazine
dc.subject.enpl
thioridazine
dc.subject.enpl
hydantoins
dc.subject.enpl
phenytoin
dc.subject.enpl
SILA 421
dc.subject.enpl
SILA 409
dc.subject.enpl
trifluoromethyl ketones
dc.subject.enpl
review
dc.subtypepl
Article
dc.titlepl
Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells
dc.title.journalpl
Anticancer Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
No affiliation
Amaral, Leonard
Spengler, Gabriella
Martins, Ana
Armada, Ana
Handzlik, Jadwiga
Kieć-Kononowicz, Katarzyna
Molnar, Joseph

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
6
Views per month
Views per city
Ashburn
2
Wroclaw
2
Dublin
1
Perth
1
Downloads
handzlik_kiec-kononowicz_et-al_inhibitors_of_bacterial_efflux_pumps_that_also_inhibit_efflux_pumps_of_cancer_cells_2012.pdf
132
handzlik_kiec-kononowicz_et-al_inhibitors_of_bacterial_efflux_pumps_that_also_inhibit_efflux_pumps_of_cancer_cells_2012.odt
95

Open Access

Thumbnail Image
License
cc-fairuse

Except where otherwise noted, this item's license is described as Fair Use

Collections
ROD UJ
Medical sciences
Research publications