Simple view

Full metadata view

Authors

Statistics

Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours

2006
journal article
article
Journal
Anticancer Research
Author
Ruschenburg Ilka

Vollheim Beate

Stachura Jerzy

Cordon-Cardo Carlos

Korabiowska Monika
Volume
26
Number
3A
Pages
2107-2112
ISSN
0250-7005
eISSN
1791-7530
Keywords in English

thyroid cancer

MLH1

MSH2

PMS1

PMS2

DNA mismatch repair

URL
http://ar.iiarjournals.org/content/26/3A/2107.full.pdf+html
Access date
2020-10-19
Remarks

Bibliogr. s. 2111-2112

Language
English
Journal language
English
Abstract in English

Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found.

Affiliation
Wydział Lekarski
dc.abstract.enAlterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found.pl
dc.affiliationWydział Lekarskipl
dc.contributor.authorRuschenburg, Ilkapl
dc.contributor.authorVollheim, Beatepl
dc.contributor.authorStachura, Jerzypl
dc.contributor.authorCordon-Cardo, Carlospl
dc.contributor.authorKorabiowska, Monikapl
dc.date.accession2020-10-19pl
dc.date.accessioned2020-10-19T08:33:01Z
dc.date.available2020-10-19T08:33:01Z
dc.date.issued2006pl
dc.date.openaccess24
dc.description.accesstimepo opublikowaniu
dc.description.additionalBibliogr. s. 2111-2112pl
dc.description.number3Apl
dc.description.physical2107-2112pl
dc.description.publication0,57pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume26pl
dc.identifier.eissn1791-7530pl
dc.identifier.issn0250-7005pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/248297
dc.identifier.weblinkhttp://ar.iiarjournals.org/content/26/3A/2107.full.pdf+htmlpl
dc.languageengpl
dc.language.containerengpl
dc.rightsDozwolony użytek utworów chronionych*
dc.rights.licenceInna otwarta licencja
dc.rights.urihttp://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf*
dc.share.typeotwarte czasopismo
dc.subject.enthyroid cancerpl
dc.subject.enMLH1pl
dc.subject.enMSH2pl
dc.subject.enPMS1pl
dc.subject.enPMS2pl
dc.subject.enDNA mismatch repairpl
dc.subtypeArticlepl
dc.titleAnalysis of DNA mismatch repair gene expression and mutations in thyroid tumourspl
dc.title.journalAnticancer Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found.
dc.affiliationpl
Wydział Lekarski
dc.contributor.authorpl
Ruschenburg, Ilka
dc.contributor.authorpl
Vollheim, Beate
dc.contributor.authorpl
Stachura, Jerzy
dc.contributor.authorpl
Cordon-Cardo, Carlos
dc.contributor.authorpl
Korabiowska, Monika
dc.date.accessionpl
2020-10-19
dc.date.accessioned
2020-10-19T08:33:01Z
dc.date.available
2020-10-19T08:33:01Z
dc.date.issuedpl
2006
dc.date.openaccess
24
dc.description.accesstime
po opublikowaniu
dc.description.additionalpl
Bibliogr. s. 2111-2112
dc.description.numberpl
3A
dc.description.physicalpl
2107-2112
dc.description.publicationpl
0,57
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
26
dc.identifier.eissnpl
1791-7530
dc.identifier.issnpl
0250-7005
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/248297
dc.identifier.weblinkpl
http://ar.iiarjournals.org/content/26/3A/2107.full.pdf+html
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dozwolony użytek utworów chronionych
dc.rights.licence
Inna otwarta licencja
dc.rights.uri*
http://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf
dc.share.type
otwarte czasopismo
dc.subject.enpl
thyroid cancer
dc.subject.enpl
MLH1
dc.subject.enpl
MSH2
dc.subject.enpl
PMS1
dc.subject.enpl
PMS2
dc.subject.enpl
DNA mismatch repair
dc.subtypepl
Article
dc.titlepl
Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours
dc.title.journalpl
Anticancer Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
No affiliation
Ruschenburg, Ilka
Vollheim, Beate
Stachura, Jerzy
Cordon-Cardo, Carlos
Korabiowska, Monika

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
4
Views per month
Views per city
Wroclaw
2
Dublin
1
Warsaw
1
Downloads
stachura_et-al_analysis_of_dna_mismatch_repair_gene_expression_and_mutations_in_thyroid_tumours_2006.pdf
30
stachura_et-al_analysis_of_dna_mismatch_repair_gene_expression_and_mutations_in_thyroid_tumours_2006.odt
3

Open Access

Thumbnail Image
License
cc-fairuse

Except where otherwise noted, this item's license is described as Fair Use

Collections
ROD UJ
Medical sciences
Research publications