Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

2018
journal article
article
21
cris.lastimport.wos2024-04-09T21:48:52Z
dc.abstract.enBackground. Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia. Methods. Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies. The distribution of genotypes for −1607 1G/2G MMP1, −735 C/T MMP2, −1306 C/T MMP2, −1171 5A/6A MMP3, and −1562C/T MMP9 polymorphisms was determined by RFLP-PCR. Results. The occurrence of 1G/1G MMP1 or 5A/5A MMP3 genotype in the mother or 1G/1G MMP1 or 5A/6A MMP3 genotype in the child is associated with preeclampsia development. Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes by over 4.5 times. No association between the carriage of studied MMP2 or MMP9 polymorphisms and the predisposition to preeclampsia was found. Conclusion. The maternal 1G/1G MMP1 and 5A/5A MMP3 and fetal 1G/1G MMP1 and 5A/6A MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.pl
dc.affiliationWydział Lekarski : Klinika Położnictwa i Perinatologiipl
dc.cm.id88973
dc.contributor.authorSakowicz, Agatapl
dc.contributor.authorLisowska, Michalinapl
dc.contributor.authorBiesiada, Lidiapl
dc.contributor.authorRybak-Krzyszkowska, Magda - 152911 pl
dc.contributor.authorGach, Agnieszkapl
dc.contributor.authorSakowicz, Bartoszpl
dc.contributor.authorGrzesiak, Mariuszpl
dc.contributor.authorHuras, Hubert - 129736 pl
dc.contributor.authorPietrucha, Tadeuszpl
dc.date.accessioned2020-09-14T12:33:45Z
dc.date.available2020-09-14T12:33:45Z
dc.date.issued2018pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.versionostateczna wersja wydawcy
dc.description.volume2018pl
dc.identifier.articleid1371425pl
dc.identifier.doi10.1155/2018/1371425pl
dc.identifier.eissn1875-8630pl
dc.identifier.issn0278-0240pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/245802
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleAssociation of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsiapl
dc.title.journalDisease Markerspl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:48:52Z
dc.abstract.enpl
Background. Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia. Methods. Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies. The distribution of genotypes for −1607 1G/2G MMP1, −735 C/T MMP2, −1306 C/T MMP2, −1171 5A/6A MMP3, and −1562C/T MMP9 polymorphisms was determined by RFLP-PCR. Results. The occurrence of 1G/1G MMP1 or 5A/5A MMP3 genotype in the mother or 1G/1G MMP1 or 5A/6A MMP3 genotype in the child is associated with preeclampsia development. Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes by over 4.5 times. No association between the carriage of studied MMP2 or MMP9 polymorphisms and the predisposition to preeclampsia was found. Conclusion. The maternal 1G/1G MMP1 and 5A/5A MMP3 and fetal 1G/1G MMP1 and 5A/6A MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.
dc.affiliationpl
Wydział Lekarski : Klinika Położnictwa i Perinatologii
dc.cm.id
88973
dc.contributor.authorpl
Sakowicz, Agata
dc.contributor.authorpl
Lisowska, Michalina
dc.contributor.authorpl
Biesiada, Lidia
dc.contributor.authorpl
Rybak-Krzyszkowska, Magda - 152911
dc.contributor.authorpl
Gach, Agnieszka
dc.contributor.authorpl
Sakowicz, Bartosz
dc.contributor.authorpl
Grzesiak, Mariusz
dc.contributor.authorpl
Huras, Hubert - 129736
dc.contributor.authorpl
Pietrucha, Tadeusz
dc.date.accessioned
2020-09-14T12:33:45Z
dc.date.available
2020-09-14T12:33:45Z
dc.date.issuedpl
2018
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
2018
dc.identifier.articleidpl
1371425
dc.identifier.doipl
10.1155/2018/1371425
dc.identifier.eissnpl
1875-8630
dc.identifier.issnpl
0278-0240
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/245802
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
dc.title.journalpl
Disease Markers
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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