Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome

2010
journal article
article
83
cris.lastimport.wos2024-04-10T01:19:18Z
dc.abstract.enOBJECTIVE - To investigate the relation between serum concentration of 25- hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS - In a cross-sectional study of 446 PanEuropean subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS - The 25(OH)D3 concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D3 levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS - In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.pl
dc.affiliationWydział Lekarski : Klinika Chorób Metabolicznychpl
dc.contributor.authorGulseth, Hanne L.pl
dc.contributor.authorGjelstad, Ingrid M.F.pl
dc.contributor.authorTierney, Audrey C.pl
dc.contributor.authorLovegrove, Julie A.pl
dc.contributor.authorDefoort, Catherinepl
dc.contributor.authorBlaak, Ellen E.pl
dc.contributor.authorLopez-Miranda, Josepl
dc.contributor.authorKieć-Wilk, Beata - 130090 pl
dc.contributor.authorRis, Ulféruspl
dc.contributor.authorRoche, Helen M.pl
dc.contributor.authorDrevon, Christian A.pl
dc.contributor.authorBirkeland, Kåre I.pl
dc.date.accessioned2020-08-27T12:29:15Z
dc.date.available2020-08-27T12:29:15Z
dc.date.issued2010pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number4pl
dc.description.physical923-925pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume33pl
dc.identifier.doi10.2337/dc09-1692pl
dc.identifier.eissn1935-5548pl
dc.identifier.issn0149-5992pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/244741
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/legalcode*
dc.share.typeinne
dc.subtypeArticlepl
dc.titleSerum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndromepl
dc.title.journalDiabetes Carepl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T01:19:18Z
dc.abstract.enpl
OBJECTIVE - To investigate the relation between serum concentration of 25- hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS - In a cross-sectional study of 446 PanEuropean subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS - The 25(OH)D3 concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D3 levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS - In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.
dc.affiliationpl
Wydział Lekarski : Klinika Chorób Metabolicznych
dc.contributor.authorpl
Gulseth, Hanne L.
dc.contributor.authorpl
Gjelstad, Ingrid M.F.
dc.contributor.authorpl
Tierney, Audrey C.
dc.contributor.authorpl
Lovegrove, Julie A.
dc.contributor.authorpl
Defoort, Catherine
dc.contributor.authorpl
Blaak, Ellen E.
dc.contributor.authorpl
Lopez-Miranda, Jose
dc.contributor.authorpl
Kieć-Wilk, Beata - 130090
dc.contributor.authorpl
Ris, Ulférus
dc.contributor.authorpl
Roche, Helen M.
dc.contributor.authorpl
Drevon, Christian A.
dc.contributor.authorpl
Birkeland, Kåre I.
dc.date.accessioned
2020-08-27T12:29:15Z
dc.date.available
2020-08-27T12:29:15Z
dc.date.issuedpl
2010
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
4
dc.description.physicalpl
923-925
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
33
dc.identifier.doipl
10.2337/dc09-1692
dc.identifier.eissnpl
1935-5548
dc.identifier.issnpl
0149-5992
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/244741
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
dc.share.type
inne
dc.subtypepl
Article
dc.titlepl
Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome
dc.title.journalpl
Diabetes Care
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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