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Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome
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Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome
Bibliographic description
| title: | Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome |
| author: | Gulseth Hanne L., Gjelstad Ingrid M.F., Tierney Audrey C., Lovegrove Julie A., Defoort Catherine, Blaak Ellen E., Lopez-Miranda Jose, Kieć-Wilk Beata  , Ris Ulférus, Roche Helen M., Drevon Christian A., Birkeland Kåre I. |
| journal title: | Diabetes Care |
| volume: | 33 |
| issue: | 4 |
| date of publication : | 2010 |
| pages: | 923-925 |
| ISSN: |
0149-5992 |
| eISSN: |
1935-5548 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | OBJECTIVE - To investigate the relation between serum concentration of 25- hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS - In a cross-sectional study of 446 PanEuropean subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS - The 25(OH)D3 concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D3 levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS - In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking. |
| affiliation: | Wydział Lekarski : Klinika Chorób Metabolicznych |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
