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Contributive sources analysis : a measure of neural networks' contribution to brain activations

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Contributive sources analysis : a measure of neural networks' contribution to brain activations

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dc.contributor.author Beldzik, Ewa [SAP14011592] pl
dc.contributor.author Domagalik-Pittner, Aleksandra [SAP14000219] pl
dc.contributor.author Daselaar, Sander pl
dc.contributor.author Fąfrowicz, Magdalena [SAP11014939] pl
dc.contributor.author Froncisz, Wojciech [SAP11004926] pl
dc.contributor.author Kontrymowicz-Ogińska, Halszka [SAP13905200] pl
dc.contributor.author Marek, Tadeusz [SAP11007137] pl
dc.date.accessioned 2014-10-30T10:34:12Z
dc.date.available 2014-10-30T10:34:12Z
dc.date.issued 2013 pl
dc.identifier.issn 1053-8119 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2206
dc.language eng pl
dc.title Contributive sources analysis : a measure of neural networks' contribution to brain activations pl
dc.type JournalArticle pl
dc.description.physical 304-312 pl
dc.abstract.en General linear model (GLM) is a standard and widely used fMRI analysis tool. It enables the detection of hypothesis-driven brain activations. In contrast, Independent Component Analysis (ICA) is a powerful technique, which enables the detection of data-driven spatially independent networks. Hybrid approaches that combine and take advantage of GLM and ICA have been proposed. Yet the choice of the best method is still a challenge, considering that the techniques may yield slightly different results regarding the number of brain regions involved in a task. A poor statistical power or the deviance from the predicted hemodynamic response functions is possible cause for GLM failures in extracting some activations picked by ICA. However, there might be another explanation for different results obtained with GLM and ICA approaches, such as networks cancelation. In this paper, we propose a new supplementary method that can give more insight into the functional data as well as help to clarify inconsistencies between the results of studies using GLM and ICA. We introduce a contributive sources analysis (CSA), which provides a measure of the number and the strength of the neural networks that significantly contribute to brain activation. CSA, applied to fMRI data of anti-saccades, enabled us to verify whether the brain regions involved in the task are dominated by a single network or serve as key nodes for particular networks interaction. Moreover, when applying CSA to the atlas-defined regions-of-interest, results indicated that activity of the parieto-medial temporal network was suppressed by the eye field network and the default mode network. Thus, this effect of networks cancelation explains the absence of parieto-medial temporal activation within the GLM results. Together, those findings indicate that brain activations are a result of complex network interactions. Applying CSA appears to be a useful tool to reveal additional findings outside the scope of the “fixed-model” GLM and data-driven ICA approaches. pl
dc.subject.en Contributive sources pl
dc.subject.en Neural networks pl
dc.subject.en Anti-saccades pl
dc.description.volume 76 pl
dc.description.number 1 pl
dc.description.publication 0,4 pl
dc.identifier.doi 10.1016/j.neuroimage.2013.03.014 pl
dc.identifier.eissn 1095-9572 pl
dc.title.journal NeuroImage pl
dc.language.container eng pl
dc.affiliation Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnej pl
dc.affiliation Pion Prorektora ds. badań naukowych i funduszy strukturalnych : Małopolskie Centrum Biotechnologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2013 A]: 45


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