MHC allele frequency distributions under parasite-driven selection : a simulation model

2010
journal article
article
29
cris.lastimport.wos2024-04-09T22:39:46Z
dc.abstract.enBackground. The extreme polymorphism that is observed in major histocompatibility complex (MHC) genes, which code for proteins involved in recognition of non-self oligopeptides, is thought to result from a pressure exerted by parasites because parasite antigens are more likely to be recognized by MHC heterozygotes (heterozygote advantage) and/or by rare MHC alleles (negative frequency-dependent selection). The Ewens-Watterson test (EW) is often used to detect selection acting on MHC genes over the recent history of a population. EW is based on the expectation that allele frequencies under balancing selection should be more even than under neutrality. We used computer simulations to investigate whether this expectation holds for selection exerted by parasites on host MHC genes under conditions of heterozygote advantage and negative frequency-dependent selection acting either simultaneously or separately. Results. In agreement with simple models of symmetrical overdominance, we found that heterozygote advantage acting alone in populations does, indeed, result in more even allele frequency distributions than expected under neutrality, and this is easily detectable by EW. However, under negative frequency-dependent selection, or under the joint action of negative frequency-dependent selection and heterozygote advantage, distributions of allele frequencies were less predictable: the majority of distributions were indistinguishable from neutral expectations, while the remaining runs resulted in either more even or more skewed distributions than under neutrality. Conclusions. Our results indicate that, as long as negative frequency-dependent selection is an important force maintaining MHC variation, the EW test has limited utility in detecting selection acting on these genes.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Nauk o Środowiskupl
dc.contributor.authorEjsmond, Maciej - 143957 pl
dc.contributor.authorBabik, Wiesław - 127155 pl
dc.contributor.authorRadwan, Jacek - 131621 pl
dc.date.accessioned2016-03-07T13:05:32Z
dc.date.available2016-03-07T13:05:32Z
dc.date.issued2010pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 8-9pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume10pl
dc.identifier.articleid332pl
dc.identifier.doi10.1186/1471-2148-10-332pl
dc.identifier.eissn1471-2148pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/21935
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 2.0*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subtypeArticlepl
dc.titleMHC allele frequency distributions under parasite-driven selection : a simulation modelpl
dc.title.journalBMC Evolutionary Biologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T22:39:46Z
dc.abstract.enpl
Background. The extreme polymorphism that is observed in major histocompatibility complex (MHC) genes, which code for proteins involved in recognition of non-self oligopeptides, is thought to result from a pressure exerted by parasites because parasite antigens are more likely to be recognized by MHC heterozygotes (heterozygote advantage) and/or by rare MHC alleles (negative frequency-dependent selection). The Ewens-Watterson test (EW) is often used to detect selection acting on MHC genes over the recent history of a population. EW is based on the expectation that allele frequencies under balancing selection should be more even than under neutrality. We used computer simulations to investigate whether this expectation holds for selection exerted by parasites on host MHC genes under conditions of heterozygote advantage and negative frequency-dependent selection acting either simultaneously or separately. Results. In agreement with simple models of symmetrical overdominance, we found that heterozygote advantage acting alone in populations does, indeed, result in more even allele frequency distributions than expected under neutrality, and this is easily detectable by EW. However, under negative frequency-dependent selection, or under the joint action of negative frequency-dependent selection and heterozygote advantage, distributions of allele frequencies were less predictable: the majority of distributions were indistinguishable from neutral expectations, while the remaining runs resulted in either more even or more skewed distributions than under neutrality. Conclusions. Our results indicate that, as long as negative frequency-dependent selection is an important force maintaining MHC variation, the EW test has limited utility in detecting selection acting on these genes.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Nauk o Środowisku
dc.contributor.authorpl
Ejsmond, Maciej - 143957
dc.contributor.authorpl
Babik, Wiesław - 127155
dc.contributor.authorpl
Radwan, Jacek - 131621
dc.date.accessioned
2016-03-07T13:05:32Z
dc.date.available
2016-03-07T13:05:32Z
dc.date.issuedpl
2010
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 8-9
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
10
dc.identifier.articleidpl
332
dc.identifier.doipl
10.1186/1471-2148-10-332
dc.identifier.eissnpl
1471-2148
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/21935
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 2.0
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/2.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subtypepl
Article
dc.titlepl
MHC allele frequency distributions under parasite-driven selection : a simulation model
dc.title.journalpl
BMC Evolutionary Biology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
11
Views per month
Views per city
Dublin
3
Wroclaw
2
Ashburn
1
Chandler
1
Des Moines
1
Downloads
ejsmond_babik_radwan_mhc_allele_frequency_distributions_2010.pdf
11
ejsmond_babik_radwan_mhc_allele_frequency_distributions_2010.odt
6