Numerous hydrotalcite-like or their derivatives have been reported as catalysts for a wide variety of chemical processes including selective reduction of nitrogen oxides with ammonia (SCR, DeNOx) or NOx storage/reduction process, selective ammonia oxidation to nitrogen and water vapour (SCO), N2O decomposition (DeN2O) and total oxidation for volatile organic compounds (VOCs). Among them manganese-containing hydrotalcite-like materials and their derivatives seems to possess high activity. This paper gives an overview of Mn-containing catalysts, including the catalyst development and their possible applications. The use of mixed metal oxides obtained from synthetic hydrotalcite-like materials mainly in the role of catalysts for the total VOCs decomposition has been reviewed. Achieved results clearly show that tested materials are candidates for potential application in real catalytic processes.