Jagiellonian University Repository

Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection


Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection

Show full item record

dc.contributor.author Skwira, Adrianna pl
dc.contributor.author Szewczyk, Adrian pl
dc.contributor.author Konopacka, Agnieszka pl
dc.contributor.author Górska, Monika pl
dc.contributor.author Majda, Dorota [SAP11018407] pl
dc.contributor.author Sądej, Rafał pl
dc.contributor.author Prokopowicz, Magdalena pl
dc.date.accessioned 2020-06-15T12:39:12Z
dc.date.available 2020-06-15T12:39:12Z
dc.date.issued 2020 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/157497
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection pl
dc.type JournalArticle pl
dc.identifier.weblink https://www.mdpi.com/1999-4923/12/1/28/htm pl
dc.abstract.en Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro. pl
dc.subject.en drug delivery system pl
dc.subject.en mesoporous silica pl
dc.subject.en silica-polymer pl
dc.subject.en ciprofloxacin pl
dc.subject.en polydimethylsiloxane pl
dc.subject.en composites pl
dc.subject.en coating blend pl
dc.description.volume 12 pl
dc.description.number 1 pl
dc.description.publication 2,3 pl
dc.identifier.doi 10.3390/pharmaceutics12010028 pl
dc.identifier.eissn 1999-4923 pl
dc.title.journal Pharmaceutics pl
dc.language.container eng pl
dc.date.accession 2020-06-15 pl
dc.affiliation Wydział Chemii : Zakład Technologii Chemicznej pl
dc.subtype Article pl
dc.identifier.articleid 28 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
.pointsMNiSW [2020 A]: 100

Files in this item

This item appears in the following Collection(s)

Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa