Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection

doi:10.3390/pharmaceutics12010028

Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection

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Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection

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dc.contributor.author	Skwira, Adrianna	pl
dc.contributor.author	Szewczyk, Adrian	pl
dc.contributor.author	Konopacka, Agnieszka	pl
dc.contributor.author	Górska, Monika	pl
dc.contributor.author	Majda, Dorota [SAP11018407]	pl
dc.contributor.author	Sądej, Rafał	pl
dc.contributor.author	Prokopowicz, Magdalena	pl
dc.date.accessioned	2020-06-15T12:39:12Z
dc.date.available	2020-06-15T12:39:12Z
dc.date.issued	2020	pl
dc.identifier.uri	https://ruj.uj.edu.pl/xmlui/handle/item/157497
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/pl/legalcode	*
dc.title	Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection	pl
dc.type	JournalArticle	pl
dc.identifier.weblink	https://www.mdpi.com/1999-4923/12/1/28/htm	pl
dc.abstract.en	Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro.	pl
dc.subject.en	drug delivery system	pl
dc.subject.en	mesoporous silica	pl
dc.subject.en	silica-polymer	pl
dc.subject.en	ciprofloxacin	pl
dc.subject.en	polydimethylsiloxane	pl
dc.subject.en	composites	pl
dc.subject.en	coating blend	pl
dc.description.volume	12	pl
dc.description.number	1	pl
dc.description.publication	2,3	pl
dc.identifier.doi	10.3390/pharmaceutics12010028	pl
dc.identifier.eissn	1999-4923	pl
dc.title.journal	Pharmaceutics	pl
dc.language.container	eng	pl
dc.date.accession	2020-06-15	pl
dc.affiliation	Wydział Chemii : Zakład Technologii Chemicznej	pl
dc.subtype	Article	pl
dc.identifier.articleid	28	pl
dc.rights.original	CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0	pl
dc.identifier.project	ROD UJ / OP	pl
.pointsMNiSW	[2020 A]: 100