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Stężenie w surowicy chorych na twardzinę skórną plackowatą i atrophoderma Pasini-Pierini z uwzględnieniem klinicznej aktywności choroby

2008
journal article
article
Journal
Postępy Dermatologii i Alergologii
Alternative title

serum level in patients with morphoea and atrophoderma Pasini-Pierini considering clinical activity of disease

Author
Lipko-Godlewska Sylwia

Wojas-Pelc Anna
Volume
25
Number
5
Pages
214-219
ISSN
1642-395X
eISSN
2299-0046
Keywords in Polish

włóknienie

cytokiny prozapalne

twardzina skórna

Keywords in English

fibrosis

proinflammatory cytokines

morphoea

URL
https://www.termedia.pl/Original-paper-INF-947-serum-level-in-patients-with-morphoea-and-atrophoderma-Pasini-Pierini-considering-clinical-activity-of-disease,7,11354,0,1.html
Access date
2020-06-08
Remarks

Bibliogr. s. 219

Language
Polish
Journal language
Polish
Abstract in English

The fundamental component in the pathogenesis of systemic scleroderma, as well as localized scleroderma, is immunologically determined fibrosis. is considered to be a strong, natural fibrosis inhibitor. Low level of this cytokine was observed in other skin diseases with the course of fibrosis. The aim of the study was to measure level in serum collected from patients with localized scleroderma. The group of localized scleroderma patients comprised 18 patients with en plaque type of localized scleroderma (M), 18 patients with atrophoderma Pasini-Pierini (APP) and 5 patients with both types of skin lesions (M + APP). Control group serum was taken from 18 healthy volunteers. level was assessed with the ELISA method. serum level was lower in all patients with localized scleroderma in comparison with the control group. serum level in patients with M + APP was also lower, whereas in patients with APP it was higher than in the control group. No statistical significance was observed. INF-\gamma serum level was significantly (p=0.04) lower in patients with the active stage of M compared with patients with the inactive one. Moreover, it was lower - but not significantly

  • in the active stage of M + APP and the whole group of patients with localized scleroderma than in inactive ones. serum level was higher only in the active stage of APP. serum level correlated with the number and area of skin lesions in all LS patients. The higher the number of skin lesions present, the lower was the serum level observed. The lowest serum level was observed in patients with greater than 30 cm2 area of skin affected by lesions (p=0.003). serum level was lower in all patients with localized scleroderma in comparison with the control group. Moreover, serum level was lower in the active stage of diseases in comparison with the inactive one. Serum level of might be a useful factor in predicting the intensity of skin fibrosis in localized scleroderma
Affiliation
Wydział Lekarski : Klinika Dermatologii
dc.abstract.enThe fundamental component in the pathogenesis of systemic scleroderma, as well as localized scleroderma, is immunologically determined fibrosis. $INF-\gamma$ is considered to be a strong, natural fibrosis inhibitor. Low level of this cytokine was observed in other skin diseases with the course of fibrosis. The aim of the study was to measure $INF-\gamma$ level in serum collected from patients with localized scleroderma. The group of localized scleroderma patients comprised 18 patients with en plaque type of localized scleroderma (M), 18 patients with atrophoderma Pasini-Pierini (APP) and 5 patients with both types of skin lesions (M + APP). Control group serum was taken from 18 healthy volunteers. $INF-\gamma$ level was assessed with the ELISA method. $INF-\gamma$ serum level was lower in all patients with localized scleroderma in comparison with the control group. $INF-\gamma$ serum level in patients with M + APP was also lower, whereas in patients with APP it was higher than in the control group. No statistical significance was observed. INF-\gamma serum level was significantly (p=0.04) lower in patients with the active stage of M compared with patients with the inactive one. Moreover, it was lower - but not significantly - in the active stage of M + APP and the whole group of patients with localized scleroderma than in inactive ones. $INF-\gamma$ serum level was higher only in the active stage of APP. $INF-\gamma$ serum level correlated with the number and area of skin lesions in all LS patients. The higher the number of skin lesions present, the lower was the $INF-\gamma$ serum level observed. The lowest $INF-\gamma$ serum level was observed in patients with greater than 30 cm2 area of skin affected by lesions (p=0.003). $INF-\gamma$ serum level was lower in all patients with localized scleroderma in comparison with the control group. Moreover, $INF-\gamma$ serum level was lower in the active stage of diseases in comparison with the inactive one. Serum level of $INF-\gamma$ might be a useful factor in predicting the intensity of skin fibrosis in localized sclerodermapl
dc.affiliationWydział Lekarski : Klinika Dermatologiipl
dc.contributor.authorLipko-Godlewska, Sylwia - 130682 pl
dc.contributor.authorWojas-Pelc, Anna - 133808 pl
dc.date.accession2020-06-08pl
dc.date.accessioned2020-06-08T12:32:11Z
dc.date.available2020-06-08T12:32:11Z
dc.date.issued2008pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 219pl
dc.description.number5pl
dc.description.physical214-219pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume25pl
dc.identifier.eissn2299-0046pl
dc.identifier.issn1642-395Xpl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/157211
dc.identifier.weblinkhttps://www.termedia.pl/Original-paper-INF-947-serum-level-in-patients-with-morphoea-and-atrophoderma-Pasini-Pierini-considering-clinical-activity-of-disease,7,11354,0,1.htmlpl
dc.languagepolpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enfibrosispl
dc.subject.enproinflammatory cytokinespl
dc.subject.enmorphoeapl
dc.subject.plwłóknieniepl
dc.subject.plcytokiny prozapalnepl
dc.subject.pltwardzina skórnapl
dc.subtypeArticlepl
dc.titleStężenie $INF-\gamma$ w surowicy chorych na twardzinę skórną plackowatą i atrophoderma Pasini-Pierini z uwzględnieniem klinicznej aktywności chorobypl
dc.title.alternative$INF-\gamma$ serum level in patients with morphoea and atrophoderma Pasini-Pierini considering clinical activity of diseasepl
dc.title.journalPostępy Dermatologii i Alergologiipl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The fundamental component in the pathogenesis of systemic scleroderma, as well as localized scleroderma, is immunologically determined fibrosis. $INF-\gamma$ is considered to be a strong, natural fibrosis inhibitor. Low level of this cytokine was observed in other skin diseases with the course of fibrosis. The aim of the study was to measure $INF-\gamma$ level in serum collected from patients with localized scleroderma. The group of localized scleroderma patients comprised 18 patients with en plaque type of localized scleroderma (M), 18 patients with atrophoderma Pasini-Pierini (APP) and 5 patients with both types of skin lesions (M + APP). Control group serum was taken from 18 healthy volunteers. $INF-\gamma$ level was assessed with the ELISA method. $INF-\gamma$ serum level was lower in all patients with localized scleroderma in comparison with the control group. $INF-\gamma$ serum level in patients with M + APP was also lower, whereas in patients with APP it was higher than in the control group. No statistical significance was observed. INF-\gamma serum level was significantly (p=0.04) lower in patients with the active stage of M compared with patients with the inactive one. Moreover, it was lower - but not significantly - in the active stage of M + APP and the whole group of patients with localized scleroderma than in inactive ones. $INF-\gamma$ serum level was higher only in the active stage of APP. $INF-\gamma$ serum level correlated with the number and area of skin lesions in all LS patients. The higher the number of skin lesions present, the lower was the $INF-\gamma$ serum level observed. The lowest $INF-\gamma$ serum level was observed in patients with greater than 30 cm2 area of skin affected by lesions (p=0.003). $INF-\gamma$ serum level was lower in all patients with localized scleroderma in comparison with the control group. Moreover, $INF-\gamma$ serum level was lower in the active stage of diseases in comparison with the inactive one. Serum level of $INF-\gamma$ might be a useful factor in predicting the intensity of skin fibrosis in localized scleroderma
dc.affiliationpl
Wydział Lekarski : Klinika Dermatologii
dc.contributor.authorpl
Lipko-Godlewska, Sylwia - 130682
dc.contributor.authorpl
Wojas-Pelc, Anna - 133808
dc.date.accessionpl
2020-06-08
dc.date.accessioned
2020-06-08T12:32:11Z
dc.date.available
2020-06-08T12:32:11Z
dc.date.issuedpl
2008
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 219
dc.description.numberpl
5
dc.description.physicalpl
214-219
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
25
dc.identifier.eissnpl
2299-0046
dc.identifier.issnpl
1642-395X
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/157211
dc.identifier.weblinkpl
https://www.termedia.pl/Original-paper-INF-947-serum-level-in-patients-with-morphoea-and-atrophoderma-Pasini-Pierini-considering-clinical-activity-of-disease,7,11354,0,1.html
dc.languagepl
pol
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
fibrosis
dc.subject.enpl
proinflammatory cytokines
dc.subject.enpl
morphoea
dc.subject.plpl
włóknienie
dc.subject.plpl
cytokiny prozapalne
dc.subject.plpl
twardzina skórna
dc.subtypepl
Article
dc.titlepl
Stężenie $INF-\gamma$ w surowicy chorych na twardzinę skórną plackowatą i atrophoderma Pasini-Pierini z uwzględnieniem klinicznej aktywności choroby
dc.title.alternativepl
$INF-\gamma$ serum level in patients with morphoea and atrophoderma Pasini-Pierini considering clinical activity of disease
dc.title.journalpl
Postępy Dermatologii i Alergologii
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations
No affiliation
Lipko-Godlewska, Sylwia
Wojas-Pelc, Anna

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