Psychiatry defines itself as a medical discipline using achievements of biology and other sciences concerned with human kind. Its methodology is borrowed from them. Biological methodology seems to be more attractive taking onto account contemporary standards of science. But, answers to questions formulated by psychiatry appear to be not satisfactory due to reduction both biological and humanistic methodology requires. Nevertheless new achievements in both approaches open new horizons for research. The main difficulty for this direction is a solid wall erected between them in a course of psychiatry development.