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Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses
Gas foaming
Bone tissue engineering
Waste material
Micro-computed tomography
In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.
dc.abstract.en | In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes. | pl |
dc.affiliation | Wydział Chemii : Zakład Chemii Nieorganicznej | pl |
dc.contributor.author | Dziadek, Michał - 423632 | pl |
dc.contributor.author | Douglas, Timothy E.L. | pl |
dc.contributor.author | Dziadek, Kinga | pl |
dc.contributor.author | Zagrajczuk, Barbara | pl |
dc.contributor.author | Serafim, Andrada | pl |
dc.contributor.author | Stancu, Izabela-Cristina | pl |
dc.contributor.author | Cholewa-Kowalska, Katarzyna | pl |
dc.date.accessioned | 2020-04-28T09:38:58Z | |
dc.date.available | 2020-04-28T09:38:58Z | |
dc.date.issued | 2020 | pl |
dc.description.publication | 0,6 | pl |
dc.description.volume | 261 | pl |
dc.identifier.articleid | 127115 | pl |
dc.identifier.doi | 10.1016/j.matlet.2019.127115 | pl |
dc.identifier.eissn | 1873-4979 | pl |
dc.identifier.issn | 0167-577X | pl |
dc.identifier.project | ROD UJ / O | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/154748 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Dodaję tylko opis bibliograficzny | * |
dc.rights.licence | Bez licencji otwartego dostępu | |
dc.rights.uri | * | |
dc.subject.en | Gas foaming | pl |
dc.subject.en | Bone tissue engineering | pl |
dc.subject.en | Waste material | pl |
dc.subject.en | Micro-computed tomography | pl |
dc.subtype | Article | pl |
dc.title | Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses | pl |
dc.title.journal | Materials Letters | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |