Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses

2020
journal article
article
16
dc.abstract.enIn this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.contributor.authorDziadek, Michał - 423632 pl
dc.contributor.authorDouglas, Timothy E.L.pl
dc.contributor.authorDziadek, Kingapl
dc.contributor.authorZagrajczuk, Barbarapl
dc.contributor.authorSerafim, Andradapl
dc.contributor.authorStancu, Izabela-Cristinapl
dc.contributor.authorCholewa-Kowalska, Katarzynapl
dc.date.accessioned2020-04-28T09:38:58Z
dc.date.available2020-04-28T09:38:58Z
dc.date.issued2020pl
dc.description.publication0,6pl
dc.description.volume261pl
dc.identifier.articleid127115pl
dc.identifier.doi10.1016/j.matlet.2019.127115pl
dc.identifier.eissn1873-4979pl
dc.identifier.issn0167-577Xpl
dc.identifier.projectROD UJ / Opl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/154748
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceBez licencji otwartego dostępu
dc.rights.uri*
dc.subject.enGas foamingpl
dc.subject.enBone tissue engineeringpl
dc.subject.enWaste materialpl
dc.subject.enMicro-computed tomographypl
dc.subtypeArticlepl
dc.titleNovel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glassespl
dc.title.journalMaterials Letterspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.contributor.authorpl
Dziadek, Michał - 423632
dc.contributor.authorpl
Douglas, Timothy E.L.
dc.contributor.authorpl
Dziadek, Kinga
dc.contributor.authorpl
Zagrajczuk, Barbara
dc.contributor.authorpl
Serafim, Andrada
dc.contributor.authorpl
Stancu, Izabela-Cristina
dc.contributor.authorpl
Cholewa-Kowalska, Katarzyna
dc.date.accessioned
2020-04-28T09:38:58Z
dc.date.available
2020-04-28T09:38:58Z
dc.date.issuedpl
2020
dc.description.publicationpl
0,6
dc.description.volumepl
261
dc.identifier.articleidpl
127115
dc.identifier.doipl
10.1016/j.matlet.2019.127115
dc.identifier.eissnpl
1873-4979
dc.identifier.issnpl
0167-577X
dc.identifier.projectpl
ROD UJ / O
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/154748
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
Bez licencji otwartego dostępu
dc.rights.uri*
dc.subject.enpl
Gas foaming
dc.subject.enpl
Bone tissue engineering
dc.subject.enpl
Waste material
dc.subject.enpl
Micro-computed tomography
dc.subtypepl
Article
dc.titlepl
Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses
dc.title.journalpl
Materials Letters
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
14
Views per month
Views per city
Ashburn
3
Chandler
2
Dublin
2
Wroclaw
2

No access

No Thumbnail Available