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Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses
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Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses
Bibliographic description
| title: | Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses |
| author: | Dziadek Michał  , Douglas Timothy E.L., Dziadek Kinga, Zagrajczuk Barbara, Serafim Andrada, Stancu Izabela-Cristina, Cholewa-Kowalska Katarzyna |
| journal title: | Materials Letters |
| volume: | 261 |
| date of publication : | 2020 |
| article ID: | 127115 |
| ISSN: |
0167-577X |
| eISSN: |
1873-4979 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes. |
| keywords in English: | Gas foaming, Bone tissue engineering, Waste material, Micro-computed tomography |
| number of pulisher's sheets: | 0,6 |
| affiliation: | Wydział Chemii : Zakład Chemii Nieorganicznej |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
