The JISP16 nucleon–nucleon potential has been applied to explore the nucleon-induced deuteron breakup process at the incoming nucleon laboratory energy E=65 MeV. We have found that the JISP16 model generally gives predictions for the differential cross section and the nucleon analysing power, which are similar to the ones obtained with the standard realistic nucleon–nucleon AV18 potential. However, there are some regions of the phase space, for which the cross section and the analysing power differ by approximately 50%. These kinematical configurations could be used to refit the JISP16 potential parameters.