Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in Alzheimer’s disease

2012
journal article
review article
9
dc.abstract.enAlzheimer’s disease is becoming an increasing problem in our aging society. According to our knowledge, so far, no effective pharmacotherapy to cure the cause of the disease has been developed. Therefore, early diagnosis is needed, which will result in implementation of a drug therapy aimed at decreasing and/or inhibiting disease development. Mass spectrometry techniques (MS) have a wide range of applications in proteomics and the search for biomarkers of neurodegenerative disorders, opening new possibilities in diagnostics. Identification of proteins in body fluids (like cerebrospinal fluid or blood) is possible due to MS spectra analysis. The detected changes in protein concentrations are connected with pathological states in an organism and, therefore, can be regarded as biomarkers. Developing procedures for proteome analysis might result in fast diagnosis, as well as creating better suited pharmaceuticals. This paper reviews the search of biomarkers in cerebrospinal fluid and blood. Later on, the use of matrix-assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in proteomics, focusing on blood-related biomarkers, is discussed. The aim of the work is also to highlight the advantages and disadvantages of MALDI-TOF-based analysespl
dc.affiliationWydział Chemii : Zakład Chemii Analitycznejpl
dc.contributor.authorGrela, Agatha - 107494 pl
dc.contributor.authorPiekoszewski, Wojciech - 160149 pl
dc.contributor.authorTurek, Agatapl
dc.date.accessioned2015-08-27T09:15:03Z
dc.date.available2015-08-27T09:15:03Z
dc.date.issued2012pl
dc.description.number8pl
dc.description.physical1297-1304pl
dc.description.points30pl
dc.description.volume50pl
dc.identifier.doi10.1515/cclm-2011-0550pl
dc.identifier.eissn1437-4331pl
dc.identifier.issn1434-6621pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/15096
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceBez licencji otwartego dostępu
dc.rights.uri*
dc.subject.enAlzheimer's diseasepl
dc.subject.enmatrix-assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)pl
dc.subject.enbiomarkerpl
dc.subject.enproteomicspl
dc.subtypeReviewArticlepl
dc.titleApplication of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in Alzheimer’s diseasepl
dc.title.journalClinical Chemistry and Laboratory Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Alzheimer’s disease is becoming an increasing problem in our aging society. According to our knowledge, so far, no effective pharmacotherapy to cure the cause of the disease has been developed. Therefore, early diagnosis is needed, which will result in implementation of a drug therapy aimed at decreasing and/or inhibiting disease development. Mass spectrometry techniques (MS) have a wide range of applications in proteomics and the search for biomarkers of neurodegenerative disorders, opening new possibilities in diagnostics. Identification of proteins in body fluids (like cerebrospinal fluid or blood) is possible due to MS spectra analysis. The detected changes in protein concentrations are connected with pathological states in an organism and, therefore, can be regarded as biomarkers. Developing procedures for proteome analysis might result in fast diagnosis, as well as creating better suited pharmaceuticals. This paper reviews the search of biomarkers in cerebrospinal fluid and blood. Later on, the use of matrix-assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in proteomics, focusing on blood-related biomarkers, is discussed. The aim of the work is also to highlight the advantages and disadvantages of MALDI-TOF-based analyses
dc.affiliationpl
Wydział Chemii : Zakład Chemii Analitycznej
dc.contributor.authorpl
Grela, Agatha - 107494
dc.contributor.authorpl
Piekoszewski, Wojciech - 160149
dc.contributor.authorpl
Turek, Agata
dc.date.accessioned
2015-08-27T09:15:03Z
dc.date.available
2015-08-27T09:15:03Z
dc.date.issuedpl
2012
dc.description.numberpl
8
dc.description.physicalpl
1297-1304
dc.description.pointspl
30
dc.description.volumepl
50
dc.identifier.doipl
10.1515/cclm-2011-0550
dc.identifier.eissnpl
1437-4331
dc.identifier.issnpl
1434-6621
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/15096
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
Bez licencji otwartego dostępu
dc.rights.uri*
dc.subject.enpl
Alzheimer's disease
dc.subject.enpl
matrix-assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)
dc.subject.enpl
biomarker
dc.subject.enpl
proteomics
dc.subtypepl
ReviewArticle
dc.titlepl
Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in Alzheimer’s disease
dc.title.journalpl
Clinical Chemistry and Laboratory Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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