Improved biodistribution, pharmacokinetics and photodynamic efficacy using a new photostable sulfonamide bacteriochlorin

2012
journal article
article
44
dc.abstract.enThe bacteriochlorin-mediated PDT effects on melanoma tumors were investigated in correlation with its biodistribution. The pharmacokinetics of the photostable 5,10,15,20-tetrakis(2,6-dichloro-3- N-ethylsulfamoylphenyl)bacteriochlorin was determined in DBA mice bearing S91 melanoma tumors at different time intervals (2 h-72 h) after i.p. injection of a 10 mg $kg^{-1}$ drug dose. PDT efficacy was maximal when irradiation was performed 24 h after i.p. administration, and led to the complete disappearance of tumors for nearly 2 months. Compared to the analogue sulfonated compound, the median tumor growth delay with respect to the control group increased from 27 to 44 days. This improvement is attributed to the higher stability, higher absorption in the NIR, amphiphilicity, and better selectivity of the sulfonamide bacteriochlorin.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizykipl
dc.contributor.authorDąbrowski, Janusz - 200579 pl
dc.contributor.authorArnaut, Luis G.pl
dc.contributor.authorPereira, Mariette M.pl
dc.contributor.authorUrbańska, Krystyna - 132487 pl
dc.contributor.authorStochel, Grażyna - 132108 pl
dc.date.accessioned2015-08-26T09:58:12Z
dc.date.available2015-08-26T09:58:12Z
dc.date.issued2012pl
dc.description.number4pl
dc.description.physical502-505pl
dc.description.volume3pl
dc.identifier.doi10.1039/C2MD00308Bpl
dc.identifier.eissn2040-2511pl
dc.identifier.issn2040-2503pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/15045
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceBez licencji otwartego dostępu
dc.rights.uri*
dc.subtypeArticlepl
dc.titleImproved biodistribution, pharmacokinetics and photodynamic efficacy using a new photostable sulfonamide bacteriochlorinpl
dc.title.journalMedChemCommpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The bacteriochlorin-mediated PDT effects on melanoma tumors were investigated in correlation with its biodistribution. The pharmacokinetics of the photostable 5,10,15,20-tetrakis(2,6-dichloro-3- N-ethylsulfamoylphenyl)bacteriochlorin was determined in DBA mice bearing S91 melanoma tumors at different time intervals (2 h-72 h) after i.p. injection of a 10 mg $kg^{-1}$ drug dose. PDT efficacy was maximal when irradiation was performed 24 h after i.p. administration, and led to the complete disappearance of tumors for nearly 2 months. Compared to the analogue sulfonated compound, the median tumor growth delay with respect to the control group increased from 27 to 44 days. This improvement is attributed to the higher stability, higher absorption in the NIR, amphiphilicity, and better selectivity of the sulfonamide bacteriochlorin.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Nieorganicznej
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki
dc.contributor.authorpl
Dąbrowski, Janusz - 200579
dc.contributor.authorpl
Arnaut, Luis G.
dc.contributor.authorpl
Pereira, Mariette M.
dc.contributor.authorpl
Urbańska, Krystyna - 132487
dc.contributor.authorpl
Stochel, Grażyna - 132108
dc.date.accessioned
2015-08-26T09:58:12Z
dc.date.available
2015-08-26T09:58:12Z
dc.date.issuedpl
2012
dc.description.numberpl
4
dc.description.physicalpl
502-505
dc.description.volumepl
3
dc.identifier.doipl
10.1039/C2MD00308B
dc.identifier.eissnpl
2040-2511
dc.identifier.issnpl
2040-2503
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/15045
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
Bez licencji otwartego dostępu
dc.rights.uri*
dc.subtypepl
Article
dc.titlepl
Improved biodistribution, pharmacokinetics and photodynamic efficacy using a new photostable sulfonamide bacteriochlorin
dc.title.journalpl
MedChemComm
dc.typepl
JournalArticle
dspace.entity.type
Publication
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