The bacteriochlorin-mediated PDT effects on melanoma tumors were investigated in correlation with
its biodistribution. The pharmacokinetics of the photostable 5,10,15,20-tetrakis(2,6-dichloro-3-
N-ethylsulfamoylphenyl)bacteriochlorin was determined in DBA mice bearing S91 melanoma tumors at
different time intervals (2 h-72 h) after i.p. injection of a 10 mg $kg^{-1}$
drug dose. PDT efficacy was
maximal when irradiation was performed 24 h after i.p. administration, and led to the complete
disappearance of tumors for nearly 2 months. Compared to the analogue sulfonated compound, the
median tumor growth delay with respect to the control group increased from 27 to 44 days. This
improvement is attributed to the higher stability, higher absorption in the NIR, amphiphilicity, and
better selectivity of the sulfonamide bacteriochlorin.
affiliation:
Wydział Chemii : Zakład Chemii Nieorganicznej, Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki