Cumulative prognostic score oredicting mortality in patients older than 80 years admitted to the ICU

2019
journal article
article
40
cris.lastimport.wos2024-04-10T03:11:27Z
dc.abstract.enOBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of 306 ICUs from 24 European countries. PARTICIPANTS Older adults admitted to European ICUs (N = 3730; median age = 84 years [interquartile range = 81‐87 y]; 51.8% male). MEASUREMENTS Overall, 24 variables available during ICU admission were included as potential predictive variables. Multivariable logistic regression was used to identify independent predictors of 30‐day mortality. Model sensitivity, specificity, and accuracy were evaluated with receiver operating characteristic curves. RESULTS The 30‐day‐mortality was 1562 (41.9%). In multivariable analysis, these variables were selected as independent predictors of mortality: age, sex, ICU admission diagnosis, Clinical Frailty Scale, Sequential Organ Failure Score, invasive mechanical ventilation, and renal replacement therapy. The discrimination, accuracy, and calibration of the model were good: the area under the curve for a score of 10 or higher was .80, and the Brier score was .18. At a cut point of 10 or higher (75% of all patients), the model predicts 30‐day mortality in 91.1% of all patients who die. CONCLUSION A predictive model of cumulative events predicts 30‐day mortality in patients older than 80 years admitted to ICUs. Future studies should include other potential predictor variables including functional status, presence of advance care plans, and assessment of each patient's decision‐making capacity.pl
dc.affiliationWydział Lekarski : Zakład Intensywnej Terapii i Medycyny Okołozabiegowejpl
dc.cm.date2020-01-07
dc.cm.id94276
dc.contributor.authorDe Lange, Dylan W.pl
dc.contributor.authorBrinkman, Sylviapl
dc.contributor.authorFlaatten, Hanspl
dc.contributor.authorBoumendil, Arianepl
dc.contributor.authorMorandi, Alessandropl
dc.contributor.authorAndersen, Finn H.pl
dc.contributor.authorArtigas, Antoniopl
dc.contributor.authorBertolini, Guidopl
dc.contributor.authorCecconi, Mauriziopl
dc.contributor.authorChristensen, Steffenpl
dc.contributor.authorFaraldi, Loredanapl
dc.contributor.authorFjolner, Jesperpl
dc.contributor.authorJung, Christianpl
dc.contributor.authorMarsh, Brianpl
dc.contributor.authorMoreno, Ruipl
dc.contributor.authorOeyen, Sandrapl
dc.contributor.authorÖhman, Christina Agvaldpl
dc.contributor.authorBollen Pinto, Bernadropl
dc.contributor.authorde Smet, Anne Marie G.A.pl
dc.contributor.authorSoliman, Ivo W.pl
dc.contributor.authorSzczeklik, Wojciech - 133561 pl
dc.contributor.authorValentin, Andreaspl
dc.contributor.authorWatson, Ximenapl
dc.contributor.authorZafeiridis, Tilemachospl
dc.contributor.authorGuidet, Bertrandpl
dc.date.accessioned2020-01-17T10:09:08Z
dc.date.available2020-01-17T10:09:08Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number6pl
dc.description.physical1263-1267pl
dc.description.points140pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume67pl
dc.identifier.doi10.1111/jgs.15888pl
dc.identifier.eissn1532-5415pl
dc.identifier.issn0002-8614pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/146163
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.encritical carepl
dc.subject.enprognosis*
dc.subject.enolder adultspl
dc.subject.enpredictpl
dc.subject.enmodelpl
dc.subtypeArticlepl
dc.titleCumulative prognostic score oredicting mortality in patients older than 80 years admitted to the ICUpl
dc.title.journalJournal of the American Geriatrics Societypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T03:11:27Z
dc.abstract.enpl
OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of 306 ICUs from 24 European countries. PARTICIPANTS Older adults admitted to European ICUs (N = 3730; median age = 84 years [interquartile range = 81‐87 y]; 51.8% male). MEASUREMENTS Overall, 24 variables available during ICU admission were included as potential predictive variables. Multivariable logistic regression was used to identify independent predictors of 30‐day mortality. Model sensitivity, specificity, and accuracy were evaluated with receiver operating characteristic curves. RESULTS The 30‐day‐mortality was 1562 (41.9%). In multivariable analysis, these variables were selected as independent predictors of mortality: age, sex, ICU admission diagnosis, Clinical Frailty Scale, Sequential Organ Failure Score, invasive mechanical ventilation, and renal replacement therapy. The discrimination, accuracy, and calibration of the model were good: the area under the curve for a score of 10 or higher was .80, and the Brier score was .18. At a cut point of 10 or higher (75% of all patients), the model predicts 30‐day mortality in 91.1% of all patients who die. CONCLUSION A predictive model of cumulative events predicts 30‐day mortality in patients older than 80 years admitted to ICUs. Future studies should include other potential predictor variables including functional status, presence of advance care plans, and assessment of each patient's decision‐making capacity.
dc.affiliationpl
Wydział Lekarski : Zakład Intensywnej Terapii i Medycyny Okołozabiegowej
dc.cm.date
2020-01-07
dc.cm.id
94276
dc.contributor.authorpl
De Lange, Dylan W.
dc.contributor.authorpl
Brinkman, Sylvia
dc.contributor.authorpl
Flaatten, Hans
dc.contributor.authorpl
Boumendil, Ariane
dc.contributor.authorpl
Morandi, Alessandro
dc.contributor.authorpl
Andersen, Finn H.
dc.contributor.authorpl
Artigas, Antonio
dc.contributor.authorpl
Bertolini, Guido
dc.contributor.authorpl
Cecconi, Maurizio
dc.contributor.authorpl
Christensen, Steffen
dc.contributor.authorpl
Faraldi, Loredana
dc.contributor.authorpl
Fjolner, Jesper
dc.contributor.authorpl
Jung, Christian
dc.contributor.authorpl
Marsh, Brian
dc.contributor.authorpl
Moreno, Rui
dc.contributor.authorpl
Oeyen, Sandra
dc.contributor.authorpl
Öhman, Christina Agvald
dc.contributor.authorpl
Bollen Pinto, Bernadro
dc.contributor.authorpl
de Smet, Anne Marie G.A.
dc.contributor.authorpl
Soliman, Ivo W.
dc.contributor.authorpl
Szczeklik, Wojciech - 133561
dc.contributor.authorpl
Valentin, Andreas
dc.contributor.authorpl
Watson, Ximena
dc.contributor.authorpl
Zafeiridis, Tilemachos
dc.contributor.authorpl
Guidet, Bertrand
dc.date.accessioned
2020-01-17T10:09:08Z
dc.date.available
2020-01-17T10:09:08Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
6
dc.description.physicalpl
1263-1267
dc.description.pointspl
140
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
67
dc.identifier.doipl
10.1111/jgs.15888
dc.identifier.eissnpl
1532-5415
dc.identifier.issnpl
0002-8614
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/146163
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
critical care
dc.subject.en*
prognosis
dc.subject.enpl
older adults
dc.subject.enpl
predict
dc.subject.enpl
model
dc.subtypepl
Article
dc.titlepl
Cumulative prognostic score oredicting mortality in patients older than 80 years admitted to the ICU
dc.title.journalpl
Journal of the American Geriatrics Society
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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