Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16

doi:10.1007/s00432-017-2531-2

Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16

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Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16

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punktacja MEiN [2018 A]: 25

title:	Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16
author:	Biesaga Beata, Mucha-Małecka Anna, Janecka-Widła Anna, Kołodziej-Rzepa Marta, Szostek Sława , Słonina Dorota, Kowalczyk Aleksandra, Halaszka Krzysztof, Przewoźnik Marcin
journal title:	Journal of Cancer Research and Clinical Oncology
volume:	144
issue:	1
date of publication :	2018
pages:	63-73
ISSN:	0171-5216
eISSN:	1432-1335
DOI:	10.1007/s00432-017-2531-2
language:	English
journal language:	English
abstract in English:	Purpose To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN). Materials and methods HPV16 presence was assessed in the group of 109 patients with HNSCCs by quantitative polymerase chain reaction (qPCR). VL (assessed by qPCR) and P16 expression (evaluated by immunohistochemistry) were analysed only in the subgroup of HPV16-positive tumours. These features were correlated with 5-year overall survival (OS) and disease-free survival (DFS). Results HPV16 infection was found in 36 tumours (33.0%). Virus-positive patients had better OS and DFS than those without infection (P = 0.041 and 0.005). Among HPV16-positive HNSCCs, 18 (50.0%) had higher VL (median value > 6764.3 copies/cell) and 25 (73.5%) P16 over expression. The significant differences in OS and DFS (P = 0.008 and 0.004) were noticed according to VL, wherein 100% DFS was found for patients with higher VL. According to P16 expression, significant difference was found only for OS (P = 0.020). In multivariate analysis, VL (P = 0.045; HR = 2.795; CI 0.121-1.060) and the level of smoking (P = 0.023, HR = 2.253; CI 1.124-4.514) were independent factors affecting DFS of HPV16-positive patients. Conclusion On the basis of viral load, it is possible to differentiate prognosis of patients with HPV16-positive HNSCCs. In this subgroup, viral load has stronger prognostic potential than P16 expression.
keywords in English:	HNSCCs, HPV16, viral load, P16 expression, Prognosis
departmental parameterization:	25
affiliation:	Wydział Lekarski : Zakład Wirusologii
type:	journal article
subtype:	academic paper