The use of the DSC method in quantification of active pharmaceutical ingredients in commercially available one component tablets

2017
journal article
article
dc.abstract.enBeside many known applications of the differential scanning calorimetry method in the study of solid phase substances, there is a possibility to use it in quantitative analysis. For this purpose, a relationship between the signal value of analyte (enthalpy change ΔH) and its concentration in the matrix is used. This paper shows how the choice of a matrix (used excipients) and the method of its preparation (as a non-micronized or micronized mixture) affect the final result of such determinations. The problem has been shown by measuring different, commercially available tablets of paracetamol. The calculated results obtained from micronized, respectively, cellulose and starch, mixtures were ranging from 456.83 mg to 491.42 mg and 465.58 mg to 486.68 mg while for non-micronized, physical mixtures were distinctly different, and were ranging, respectively, from 433.27 mg to 455.12 mg and 449.04 to 473.36 mg. The DSC method was validated and as a reference, a validated TLC method with densitometric detection was used.pl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Analitycznejpl
dc.cm.date2020-01-07
dc.cm.id83719
dc.contributor.authorTalik, Przemysław - 200522 pl
dc.contributor.authorŻuromska-Witek, Barbara - 200539 pl
dc.contributor.authorHubicka, Urszula - 129734 pl
dc.contributor.authorKrzek, Jan - 130468 pl
dc.date.accession2019-05-29pl
dc.date.accessioned2020-01-17T09:16:41Z
dc.date.available2020-01-17T09:16:41Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 1054-1055pl
dc.description.number4pl
dc.description.physical1049-1055pl
dc.description.points15pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume74pl
dc.identifier.eissn2353-5288pl
dc.identifier.issn0001-6837pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/140960
dc.identifier.weblinkhttp://ptfarm.pl/en/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/26981pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.endifferential scanning calorimetrypl
dc.subject.enDSCpl
dc.subject.encalorimetrypl
dc.subject.enparacetamolpl
dc.subject.enacetaminophenpl
dc.subtypeArticlepl
dc.titleThe use of the DSC method in quantification of active pharmaceutical ingredients in commercially available one component tabletspl
dc.title.journalActa Poloniae Pharmaceutica. Drug Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Beside many known applications of the differential scanning calorimetry method in the study of solid phase substances, there is a possibility to use it in quantitative analysis. For this purpose, a relationship between the signal value of analyte (enthalpy change ΔH) and its concentration in the matrix is used. This paper shows how the choice of a matrix (used excipients) and the method of its preparation (as a non-micronized or micronized mixture) affect the final result of such determinations. The problem has been shown by measuring different, commercially available tablets of paracetamol. The calculated results obtained from micronized, respectively, cellulose and starch, mixtures were ranging from 456.83 mg to 491.42 mg and 465.58 mg to 486.68 mg while for non-micronized, physical mixtures were distinctly different, and were ranging, respectively, from 433.27 mg to 455.12 mg and 449.04 to 473.36 mg. The DSC method was validated and as a reference, a validated TLC method with densitometric detection was used.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Analitycznej
dc.cm.date
2020-01-07
dc.cm.id
83719
dc.contributor.authorpl
Talik, Przemysław - 200522
dc.contributor.authorpl
Żuromska-Witek, Barbara - 200539
dc.contributor.authorpl
Hubicka, Urszula - 129734
dc.contributor.authorpl
Krzek, Jan - 130468
dc.date.accessionpl
2019-05-29
dc.date.accessioned
2020-01-17T09:16:41Z
dc.date.available
2020-01-17T09:16:41Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 1054-1055
dc.description.numberpl
4
dc.description.physicalpl
1049-1055
dc.description.pointspl
15
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
74
dc.identifier.eissnpl
2353-5288
dc.identifier.issnpl
0001-6837
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/140960
dc.identifier.weblinkpl
http://ptfarm.pl/en/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/26981
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
differential scanning calorimetry
dc.subject.enpl
DSC
dc.subject.enpl
calorimetry
dc.subject.enpl
paracetamol
dc.subject.enpl
acetaminophen
dc.subtypepl
Article
dc.titlepl
The use of the DSC method in quantification of active pharmaceutical ingredients in commercially available one component tablets
dc.title.journalpl
Acta Poloniae Pharmaceutica. Drug Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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