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CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma
malignant melanoma
dendritic cells
Introduction: Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy. Material and methods: The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma. Results: Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for in situ lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for in situ lesions and 150.78
- for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage (R = 0.59) mitotic activity within the tumor (R = 0.62). Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69). Conclusions: CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies.
cris.lastimport.wos | 2024-04-09T21:55:49Z | |
dc.abstract.en | Introduction: Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy. Material and methods: The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma. Results: Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for in situ lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for in situ lesions and 150.78 - for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage (R = 0.59) mitotic activity within the tumor (R = 0.62). Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69). Conclusions: CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies. | pl |
dc.affiliation | Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej | pl |
dc.affiliation | Wydział Lekarski : Klinika Pulmonologii | pl |
dc.cm.date | 2020-01-07 | |
dc.cm.id | 83309 | |
dc.contributor.author | Dyduch, Grzegorz - 129300 | pl |
dc.contributor.author | Tyrak, Katarzyna - 187123 | pl |
dc.contributor.author | Glajcar, Anna - 148470 | pl |
dc.contributor.author | Szpor, Joanna - 133600 | pl |
dc.contributor.author | Okoń, Krzysztof - 133027 | pl |
dc.date.accessioned | 2020-01-17T09:16:36Z | |
dc.date.available | 2020-01-17T09:16:36Z | |
dc.date.issued | 2017 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.number | 3 | pl |
dc.description.physical | 233-239 | pl |
dc.description.points | 15 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 34 | pl |
dc.identifier.doi | 10.5114/ada.2017.67845 | pl |
dc.identifier.eissn | 2299-0046 | pl |
dc.identifier.issn | 1642-395X | pl |
dc.identifier.project | ROD UJ / OP | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/140824 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa | * |
dc.rights.licence | CC-BY-NC-SA | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl | * |
dc.share.type | otwarte czasopismo | |
dc.subject.en | malignant melanoma | pl |
dc.subject.en | dendritic cells | pl |
dc.subtype | Article | pl |
dc.title | CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma | pl |
dc.title.journal | Postępy Dermatologii i Alergologii | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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