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CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma
Bibliographic description
| title: | CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma |
| author: | Dyduch Grzegorz  , Tyrak Katarzyna , Glajcar Anna , Szpor Joanna , Okoń Krzysztof
|
| journal title: | Postępy Dermatologii i Alergologii |
| volume: | 34 |
| issue: | 3 |
| date of publication : | 2017 |
| pages: | 233-239 |
| ISSN: |
1642-395X |
| eISSN: |
2299-0046 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Introduction: Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy. Material and methods: The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma. Results: Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for in situ lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for in situ lesions and 150.78 - for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage (R = 0.59) mitotic activity within the tumor (R = 0.62). Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69). Conclusions: CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies. |
| keywords in English: | malignant melanoma, dendritic cells |
| departmental parameterization: | 15 |
| affiliation: | Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej, Wydział Lekarski : Klinika Pulmonologii |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
