Introduction: Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is
however a matter of controversy.
Material and methods: The number of dendritic cells within epidermis and in peri- and intratumoral location was
analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma.
Results: Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for in situ lesions and 26.24 for
invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for in situ lesions and 150.78
- for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with
Breslow stage (R = 0.59) mitotic activity within the tumor (R = 0.62). Invasive cases with regression showed higher
intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but
lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral
and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69).
Conclusions: CD207+ cells play a role in both progression and regression of melanoma but their exact role needs
further studies.
keywords in English:
malignant melanoma, dendritic cells
departmental parameterization:
15
affiliation:
Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej, Wydział Lekarski : Klinika Pulmonologii
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