Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland
author:
Różańska Anna , Wójkowska-Mach Jadwiga , Adamski P., Borszewska-Kornacka Maria, Gulczyńska E., Nowiczewski M., Helwich E., Kordek A., Pawlik Dorota , Bulanda Małgorzata
journal title:
Annals of Clinical Microbiology and Antimicrobials
Background: Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic
therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usage
in bloodstream infections treatment in the Polish Neonatology Surveillance Network (PNSN) and determining the
possibility of applying this kind of data in infection control, especially for the evaluation of standard methods of
microbiological diagnostics.
Methods: Data were collected between 01.01.2009 and 31.12.2013 in five teaching NICUs from the PNSN. The
duration of treatment in days (DOT) and the defined daily doses (DDD) were used for the assessment of antibiotics
consumption.
Results: The median DOT for a single case of BSI amounted to 8.0 days; whereas the median consumption expressed
in DDD was 0.130. In the case of laboratory confirmed BSI, median DOT was 8 days, and consumption—0.120 DDD.
Median length of therapy was shorter for unconfirmed cases: 7 days, while the consumption of antibiotics was
higher—0.140 DDD (p < 0.0001). High consumption of glycopeptides expressed in DOTs was observed in studied
population, taking into account etiology of infection.
Conclusions: Even application of classical methods of microbiological diagnostics significantly reduces the consumption
of antibiotics expressed by DDD. However, the high consumption of glycopeptides indicates the necessity
of applying rapid diagnostic assays. Nevertheless, the assessment of antibiotic consumption in neonatal units represents
a methodological challenge and requires the use of different measurement tools.
Wydział Lekarski : Zakład Epidemiologii Zakażeń, Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii, Wydział Lekarski : Klinika Neonatologii