Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland

2017
journal article
article
9
dc.abstract.enBackground: Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usage in bloodstream infections treatment in the Polish Neonatology Surveillance Network (PNSN) and determining the possibility of applying this kind of data in infection control, especially for the evaluation of standard methods of microbiological diagnostics. Methods: Data were collected between 01.01.2009 and 31.12.2013 in five teaching NICUs from the PNSN. The duration of treatment in days (DOT) and the defined daily doses (DDD) were used for the assessment of antibiotics consumption. Results: The median DOT for a single case of BSI amounted to 8.0 days; whereas the median consumption expressed in DDD was 0.130. In the case of laboratory confirmed BSI, median DOT was 8 days, and consumption—0.120 DDD. Median length of therapy was shorter for unconfirmed cases: 7 days, while the consumption of antibiotics was higher—0.140 DDD (p < 0.0001). High consumption of glycopeptides expressed in DOTs was observed in studied population, taking into account etiology of infection. Conclusions: Even application of classical methods of microbiological diagnostics significantly reduces the consumption of antibiotics expressed by DDD. However, the high consumption of glycopeptides indicates the necessity of applying rapid diagnostic assays. Nevertheless, the assessment of antibiotic consumption in neonatal units represents a methodological challenge and requires the use of different measurement tools.pl
dc.affiliationWydział Lekarski : Zakład Epidemiologii Zakażeńpl
dc.affiliationWydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologiipl
dc.affiliationWydział Lekarski : Klinika Neonatologiipl
dc.cm.date2020-01-07
dc.cm.id82102
dc.contributor.authorRóżańska, Anna - 133303 pl
dc.contributor.authorWójkowska-Mach, Jadwiga - 133844 pl
dc.contributor.authorAdamski, P.pl
dc.contributor.authorBorszewska-Kornacka, Mariapl
dc.contributor.authorGulczyńska, E.pl
dc.contributor.authorNowiczewski, M.pl
dc.contributor.authorHelwich, E.pl
dc.contributor.authorKordek, A.pl
dc.contributor.authorPawlik, Dorota - 133107 pl
dc.contributor.authorBulanda, Małgorzata - 128927 pl
dc.date.accessioned2020-01-17T09:15:39Z
dc.date.available2020-01-17T09:15:39Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.points20pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume16pl
dc.identifier.articleid20pl
dc.identifier.doi10.1186/s12941-017-0196-ypl
dc.identifier.eissn1476-0711
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/140518
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enantimicrobial consumptionpl
dc.subject.eninfection surveillancepl
dc.subject.enbloodstream infectionspl
dc.subject.enneonatal infectionspl
dc.subtypeArticlepl
dc.titleAntibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Polandpl
dc.title.journalAnnals of Clinical Microbiology and Antimicrobialspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background: Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usage in bloodstream infections treatment in the Polish Neonatology Surveillance Network (PNSN) and determining the possibility of applying this kind of data in infection control, especially for the evaluation of standard methods of microbiological diagnostics. Methods: Data were collected between 01.01.2009 and 31.12.2013 in five teaching NICUs from the PNSN. The duration of treatment in days (DOT) and the defined daily doses (DDD) were used for the assessment of antibiotics consumption. Results: The median DOT for a single case of BSI amounted to 8.0 days; whereas the median consumption expressed in DDD was 0.130. In the case of laboratory confirmed BSI, median DOT was 8 days, and consumption—0.120 DDD. Median length of therapy was shorter for unconfirmed cases: 7 days, while the consumption of antibiotics was higher—0.140 DDD (p < 0.0001). High consumption of glycopeptides expressed in DOTs was observed in studied population, taking into account etiology of infection. Conclusions: Even application of classical methods of microbiological diagnostics significantly reduces the consumption of antibiotics expressed by DDD. However, the high consumption of glycopeptides indicates the necessity of applying rapid diagnostic assays. Nevertheless, the assessment of antibiotic consumption in neonatal units represents a methodological challenge and requires the use of different measurement tools.
dc.affiliationpl
Wydział Lekarski : Zakład Epidemiologii Zakażeń
dc.affiliationpl
Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii
dc.affiliationpl
Wydział Lekarski : Klinika Neonatologii
dc.cm.date
2020-01-07
dc.cm.id
82102
dc.contributor.authorpl
Różańska, Anna - 133303
dc.contributor.authorpl
Wójkowska-Mach, Jadwiga - 133844
dc.contributor.authorpl
Adamski, P.
dc.contributor.authorpl
Borszewska-Kornacka, Maria
dc.contributor.authorpl
Gulczyńska, E.
dc.contributor.authorpl
Nowiczewski, M.
dc.contributor.authorpl
Helwich, E.
dc.contributor.authorpl
Kordek, A.
dc.contributor.authorpl
Pawlik, Dorota - 133107
dc.contributor.authorpl
Bulanda, Małgorzata - 128927
dc.date.accessioned
2020-01-17T09:15:39Z
dc.date.available
2020-01-17T09:15:39Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.pointspl
20
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
16
dc.identifier.articleidpl
20
dc.identifier.doipl
10.1186/s12941-017-0196-y
dc.identifier.eissn
1476-0711
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/140518
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
antimicrobial consumption
dc.subject.enpl
infection surveillance
dc.subject.enpl
bloodstream infections
dc.subject.enpl
neonatal infections
dc.subtypepl
Article
dc.titlepl
Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland
dc.title.journalpl
Annals of Clinical Microbiology and Antimicrobials
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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