Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej

doi:10.12740/PP/OnlineFirst/65250

Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej

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Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej

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punktacja MEiN [2017 A]: 15

title:	Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej
alternative title:	The serum concentration of copper in bipolar disorder
author:	Siwek Marcin , Styczeń Krzysztof , Sowa-Kućma Magdalena, Dudek Dominika , Reczyński Witold, Szewczyk Bernadeta, Misztak Paulina , Opoka Włodzimierz , Topór-Mądry Roman , Nowak Gabriel , Rybakowski Janusz K.
journal title:	Psychiatria Polska
volume:	51
issue:	3
date of publication :	2017
pages:	469-481
ISSN:	0033-2674
eISSN:	2391-5854
DOI:	10.12740/PP/OnlineFirst/65250
language:	Polish
journal language:	Polish
abstract in English:	Aim. Some scientific reports indicate the changes in the concentration of serum copper in patients with bipolar disorder (BD), however the data are inconclusive. The aim of this study was to assess the concentration of copper in the blood serum of patients in various phases of BD compared to healthy volunteers, taking into consideration the specific clinical features, and the stage of illness. Methods. The study enrolled 133 patients with a diagnosis of BD (type I, II and NOS), including 61 people in depressive episode, 23 in mania or hypomania and 49 in remission. The control group consisted of 50 people. Atomic absorption spectrometry was used to measure the concentration of copper. Results. There were no statistically significant differences in the serum copper concentration between patients in various phases of BD (mania/hypomania, depression, remission), sub-types (Type I, Type II + NOS) or stages and healthy volunteers. However, serum copper concentrations in patients in stage 1 was significantly higher than in advanced stages (2+3+4), (β = 0.22; p = 0.02). Serum copper concentration was also the higher, the later the age of onset was (β = 0.33; p < 0.001), and the lower, the greater the number of illness episodes (β = – 0.23; p = 0.02) (multiple regression model, adj R2 = 0.19, p = 0.0001). Conclusions. The dependencies demonstrated above may reflect pathophysiological processes that occur in the course of BD (e.g., inflammatory response and oxidative stress) with a different intensity depending on its stage.
keywords in Polish:	choroba afektywna dwubiegunowa, biomarkery, miedź
keywords in English:	bipolar disorder, biomarkers, copper
departmental parameterization:	15
affiliation:	Wydział Farmaceutyczny : Katedra Farmakobiologii, Wydział Farmaceutyczny : Zakład Chemii Nieorganicznej, Wydział Farmaceutyczny : Zakład Cytobiologii, Wydział Lekarski : Zakład Zaburzeń Afektywnych, Wydział Lekarski : Klinika Psychiatrii Dorosłych, Wydział Nauk o Zdrowiu : Instytut Zdrowia Publicznego
type:	journal article
subtype:	academic paper