Progestogens in menopausal hormone therapy

2015
journal article
review article
31
cris.lastimport.wos2024-04-09T20:34:09Z
dc.abstract.enProgestogens share one common effect: the ability to convert proliferative endometrium to its secretory form. In contrast, their biological activity is varied, depending on the chemical structure, pharmacokinetics, receptor affinity and different potency of action. Progestogens are widely used in the treatment of menstrual cycle disturbances, various gynaecological conditions, contraception and menopausal hormone therapy. The administration of progestogen in menopausal hormone therapy is essential in women with an intact uterus to protect against endometrial hyperplasia and cancer. Progestogen selection should be based on the characteristics available for each progestogen type, relying on the assessment of relative potency of action in experimental models and animal models, and on the indirect knowledge brought by studies of the clinical use of different progestogen formulations. The choice of progestogen should involve the conscious use of knowledge of its benefits, with a focus on minimizing potential side effects. Unfortunately, there are no direct clinical studies comparing the metabolic effects of different progestogens.pl
dc.affiliationWydział Lekarski : Zakład Farmakologii Klinicznejpl
dc.cm.date2020-01-07
dc.cm.id73064
dc.contributor.authorBińkowska, Małgorzatapl
dc.contributor.authorWoroń, Jarosław - 133825 pl
dc.date.accessioned2020-01-17T08:49:42Z
dc.date.available2020-01-17T08:49:42Z
dc.date.issued2015pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number2pl
dc.description.physical134-143pl
dc.description.points8pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume14pl
dc.identifier.doi10.5114/pm.2015.52154pl
dc.identifier.eissn2299-0038pl
dc.identifier.issn1643-8876pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/135771
dc.languageengpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enprogestogenspl
dc.subject.enmenopausal hormonepl
dc.subject.entherapypl
dc.subject.enprogesteronepl
dc.subject.enprogestinpl
dc.subtypeReviewArticlepl
dc.titleProgestogens in menopausal hormone therapypl
dc.title.journalPrzegląd Menopauzalnypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T20:34:09Z
dc.abstract.enpl
Progestogens share one common effect: the ability to convert proliferative endometrium to its secretory form. In contrast, their biological activity is varied, depending on the chemical structure, pharmacokinetics, receptor affinity and different potency of action. Progestogens are widely used in the treatment of menstrual cycle disturbances, various gynaecological conditions, contraception and menopausal hormone therapy. The administration of progestogen in menopausal hormone therapy is essential in women with an intact uterus to protect against endometrial hyperplasia and cancer. Progestogen selection should be based on the characteristics available for each progestogen type, relying on the assessment of relative potency of action in experimental models and animal models, and on the indirect knowledge brought by studies of the clinical use of different progestogen formulations. The choice of progestogen should involve the conscious use of knowledge of its benefits, with a focus on minimizing potential side effects. Unfortunately, there are no direct clinical studies comparing the metabolic effects of different progestogens.
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii Klinicznej
dc.cm.date
2020-01-07
dc.cm.id
73064
dc.contributor.authorpl
Bińkowska, Małgorzata
dc.contributor.authorpl
Woroń, Jarosław - 133825
dc.date.accessioned
2020-01-17T08:49:42Z
dc.date.available
2020-01-17T08:49:42Z
dc.date.issuedpl
2015
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
2
dc.description.physicalpl
134-143
dc.description.pointspl
8
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
14
dc.identifier.doipl
10.5114/pm.2015.52154
dc.identifier.eissnpl
2299-0038
dc.identifier.issnpl
1643-8876
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/135771
dc.languagepl
eng
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
progestogens
dc.subject.enpl
menopausal hormone
dc.subject.enpl
therapy
dc.subject.enpl
progesterone
dc.subject.enpl
progestin
dc.subtypepl
ReviewArticle
dc.titlepl
Progestogens in menopausal hormone therapy
dc.title.journalpl
Przegląd Menopauzalny
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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